Compulsive-like behaviors in DISC1-mice

Poster (download)

355

Nadezhda Chizhova¹, Kristina Smirnova^2
1ICG SB RAS, chnadezhda1995@gmail.com
²NSU, PhBMRI, vedelina@mail.ru

The DISC1 gene is associated with the development of mental disorders in humans. Currently a number of genetic models of psychopathologies withВ  mutations in the gene have been created, including genetic lines of mice with point mutations DISC1-Q31L^-/- (model of depression) and DISC1-L100P^-/- (model of schizophrenia), which are available at the unique scientific installation “Biological collection – genetic biomodels of neuropsychiatric diseases” (State Scientific-Research Institute of Physiology and Basic Medicine, Novosibirsk). In additional mice DISC1-Q31L^-/- showed compulsive-like behavior, and in this connection was proposed to study this type of behavior in heterozygotes and diheterozygotes for these mutations. The work performed allows us to conclude that the presence of only one mutant allele (both DISC1-Q31L and DISC1-L100P) is not sufficient for the expression of compulsive-like behavior in mice. However, mice that combine both mutations are predisposed to this behavior and exhibit it depending on their sex and mother’s genotype: this behaviour characterise males whose mothers were homozygous for DISC1-Q31L mutation, and females whose mothers were homozygous for DISC1-L100P mutation. The conclusion about the influence of homozygosity and, accordingly, the behavior of mothers on the compulsive-like behavior of females and males can be verified in further experiments.