Functional annotation of the transcription factors from Methylotuvimicrobium alcaliphilum 20ZR

Semyon K. Kolmykov1, Nikita V. Ivanisenko2, Ivan S. Evshin3, Mikhail Kulyashov4, Tamara M. Khlebodarova5, Ilya R. Akberdin6
1Institute of Computational Technologies SB RAS, kolmykovsk@gmail.com
2FRC Institute of Cytology and Genetics SB RAS, n.ivanisenko@gmail.com
3Institute of Computational Technologies SB RAS, ivan@biosoft.ru
4Institute of Computational Technologies SB RAS, m.kulyashov@mail.ru
5FRC Institute of Cytology and Genetics SB RAS, tamara@bionet.nsc.ru
6FRC Institute of Cytology and Genetics SB RAS, akberdinir@gmail.com

Methane is a promising carbon source for biosynthesis of biotechnologically useful compounds using aerobic methanotrophic bacteria as biocatalysts. Despite more than a century-long history of discovering and studying of methanotrophic microorganisms, knowledge of the molecular mechanisms of gene expression regulation by transcription factors in these bacteria is very limited with only a few isolated cases being published. Therefore, the identification of potential transcription factors for methanotrophic organisms and their target genes is not only a foreground fundamental problem in the research field of methanotrophy, but it is also especially relevant for the active development of biotechnological application of methane-oxidizing microorganisms. In this study a comparative genomics approach together with the structural modeling techniques were applied to reveal the TFs in the 20ZR genome and predict their target regulatory genes.

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