Genomic Signals of Adaptation in the Northern Ural and Western Siberian Populations

Poster (download)

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Gennady Khvorykh¹, Giang Vu², Andrey Khrunin³
¹Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia, khvorykh@img.ras.ru
²Moscow Polytechnic University, Moscow, Russia, vuminhgiang135@gmail.com
³Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia, khrunin@img.ras.ru

The evolution of humans was influenced by environmental conditions, particularly when they left Africa. Exploration of the genetic variations in the populations leaving in extreme climates will lead to better understanding of molecular-genetics mechanisms of adaptation. In the current study we investigated the genome-wide data of Khahty, Mansi, and Nenets people for signatures of selection using the population branch statistic test and revealed strong signals located in a cluster of alcohol dehydrogenase 1 genes. We hypothesize that it can be due to the limited diversity of food intake the indigenous people of the Northern Ural and Siberian experience.