MAPK pathways and alphaB-crystallin phosphorylation in brain: a focus on aging and Alzheimer’s disease

Poster (download)

147

Natalia Muraleva1
1Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, myraleva@bionet.nsc.ru

Accumulation of intracellular damage and protein aggregates is an universal hallmark of aging and accompanies the development of some age-related diseases include Alzheimer’s disease (AD). Alpha-B-Crystallin (CryaB) as the molecular chaperone contributes maintenance of proteostasis by prevention of aggregation of proteins (e.g. amyloid beta) and enables their correct refolding. CryaB activity is regulated by MAPK signaling pathway (MAPKsp) through its phosphorylation. Nevertheless, the link between changes in MAPK-dependent CryaB phosphorylation with age and the development of AD remains unclear. Here, we examined p38 MAPK- and ERK-dependent phosphorylation of CryaB in the brain of Wistar rats with normal aging and senescence-accelerated OXYS rats at the different stages of the development of AD-like pathology, including the presymptomatic stage.  The most significant changes identified in the p38 MAPK-dependent CryaB phosphorylation. The level of p-Ser59-CryaB in the brain of Wistar rats increased with the age on the background of p38-MAPKsp activation. Similar but more significant changes accompanied the development of AD-like pathology in OXYS rats. The activation of ERK1/2-dependent CryaB phosphorylation (p-Ser45-CryaB) was detected at the early age and at the late stages of AD-like pathology in OXYS, while changes in the ERK1/2 signaling pathway were detected in Wistar rats with age. Thus, alteration of MAPK-dependent phosphorylation CryaB occurs with the normal aging. Manifestation and progression of the signs of the AD occurs against the background of activation of p38MAPK-dependent phosphorylation of CryaB. Activation of EPK-dependent CryaB phosphorylation is characteristic of the preclinical and progressive stage of the AD-like pathology.

0 0 vote
Article Rating
Subscribe
Notify of
guest
16 Comments
Inline Feedbacks
View all comments
exquisite jazz
5 months ago

exquisite jazz

summer coffee shop
5 months ago

summer coffee shop

relax music
5 months ago

relax music

soothing piano
5 months ago

soothing piano

bossa nova
5 months ago

bossa nova

cafe sound effect
5 months ago

cafe sound effect

ocean cafe ambience
5 months ago

ocean cafe ambience

Spa Music
5 months ago

Spa Music

positive november jazz
4 months ago

positive november jazz

jazz for improve moods
4 months ago

jazz for improve moods

workout music motivation

workout music motivation

sleep meditation
3 months ago

sleep meditation

healing meditation
3 months ago

healing meditation

jazz music for sleep
3 months ago

jazz music for sleep

cozy cafe
3 months ago

cozy cafe

relaxing piano
3 months ago

relaxing piano