Egor Plotnikov1, Nadezda Andrianova2, Stanislovas Jankauskas3, Irina Pevzner4, Ljubava Zorova5, Vasily Popkov6, Denis Silachev7, Natalia Kolosova8, Dmitry Zorov9
1A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, plotnikov@belozersky.msu.ru
2A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, andnadya12@gmail.com
3A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, jankauskas.ss@gmail.com
4A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, irinapevzner@mail.ru
5A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, lju_2003@list.ru
6A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, popkov.vas@gmail.com
7A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, silachev_dn@belozersky.msu.ru
8Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), kolosova@bionet.nsc.ru
9A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, zorov@belozersky.msu.ru
Dietary restriction and ischemic preconditioning are the most efficient approaches ameliorating the severity of different pathological conditions. We investigated the protective potential of long-term calorie restriction and short ischemic preconditioning protocol in the model of acute kidney injury (AKI) in young Wistar and OXYS rats. In young rats, ischemic preconditioning, which consists of 4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However, 6-month-old OXYS rats having signs of premature aging lost their ability to protect the ischemic kidney by IPC. However, CR of OXYS rats led to a significant decrease in creatinine and BUN levels after kidney ischemia, indicating significant protection.
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