Reconstruction and Analysis of Regulatory Gene Networks Involving Human Genes Associated with Main Forms of Pathozoospermia

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Elena V. Ignatieva1, Alexander V. Osadchuk2, Maxim A Kleshev3, Ludmila V. Osadchuk4
1The Federal Research Center Institute of Cytology and Genetics, SB RAS, eignat@bionet.nsc.ru
2The Federal Research Center Institute of Cytology and Genetics, SB RAS, osadchuk@bionet.nsc.ru
3The Federal Research Center Institute of Cytology and Genetics, SB RAS, max82cll@bionet.nsc.ru
4The Federal Research Center Institute of Cytology and Genetics, SB RAS, losadch@bionet.nsc.ru

The study of the molecular-genetic mechanisms predisposing to decline in male reproductive potential (spermatogenic failure) is an actual problem of reproductive biology. Most often in laboratory studies evaluating male fertility, a study of the quality of ejaculate is used. Thus, a pathological condition called pathozoospermia can be detected if the quality indicators of the ejaculate are decreased. Pathozoospermia can manifest itself in several distinct forms, may occur in many diseases and can be caused by many factors, including genetic ones. To reveal regulatory interactions between genes associated with pathozoospermia, we reconstructed gene regulatory network involving genes harboring allelic variants associated with pathozoospermia. Regulatory network comprised seven genes encoding transcription factors (TFs) for which a set of target genes were predicted by MoLoTool web-service. We identified three key regulatory transcription factors (WT1, AHR, NR0B1) that have the greatest number of target genes in the network. Genes encoding these factors can be considered as the most promising candidate genes for identifying genetic variants associated with pathozoospermia.

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