The rs12255372 and rs7903146 polymorphisms of the TCF7L2 gene among Buryats and Russians of Eastern Siberia.

Poster (download)

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Ludmila Tabikhanova¹, Ludmila Osipova², Tatiana Churkina³, Daria Lichman⁴, Elena Voronina⁵, Maxim Filipenko^6
1Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk State University, tabikhan@bionet.nsc.ru
²Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk State University, ludos77@yandex.ru
³Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk State University, tan646464@gmail.com
⁴Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk State University, daria.lichman@gmail.com
⁵Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk State University, voronina_l@mail.ru
⁶Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk State University, max@niboch.nsc.ru

The objective of the present study was to investigate the polymorphism of metabolism genes in indigenous populations of Siberia. To this end, we have studied the ethnic features of allele frequency distribution for polymorphic variants in gene TCF7L2 G103894T (rs12255372) and C53341T (rs7903146) in the samples taken from Buryats, and Russians of Eastern Siberia, and compared it with data on world populations. Samples of Eastern (N = 132) and Western (N = 278) Buryats, Russians (N = 122) and persons of mixed Buryat-Russian origin (N = 56) were genotyped by real-time PCR using competitive TaqMan- probes. Compared to the Russians, the Buryats showed a statistically significantly lower incidence of the TCF7L2 103894T and TCF7L2 53341T alleles associated with metabolic diseases and Type 2 diabetes mellitus (T2DM). Buryats are intermediate between Caucasian and East Asian populations. This agrees with the lower susceptibility of Buryats to metabolic disorders compared to the Caucasian population described in the literature. Intermediate frequencies alleles in the group of mixed origin may indicate a higher risk of the associated metabolic disorders in the descendants of mixed marriages compared to the Buryats.