The structure of the cytokine gene network in uterine fibroids

Poster (download)

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Viktor Prokofiev¹, Alla Shevchenko², Vladimir Konenkov³, Nikolay Orlov⁴, Elena Koroleva⁵, Alexey Novikov^6
1Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, vf_prok@mail.ru
²Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, shalla64@mail.ru
³Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, vikonenkov@gmail.com
⁴Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, nbo700@mail.ru
⁵Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, lymphology@niikel.ru
⁶Research Institute of Clinical and Experimental LymСЂhology – Branch of the Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, novis.ngmu@gmail.com

The structure of 166416 gene chains of various dimensions consisting of multilocus combinations of genes of 12 polymorphic sites forming a cytokine gene network associated with the development of uterine fibroids (UF) was studied.В  Using the Cytoscape bioinformation platform, computer modeling of network interactions of cytokine genotypes of various nature involved in the regulation of inflammation, angiogenesis, destruction and remodeling of connective tissue involved in the pathogenesis of polygenic diseases, including UF, was carried out.В  An analysis of the topology of this gene network made it possible to identify the main genes and the main intergenic interactions that make the greatest contribution to the development of UF.В  In our opinion, 3 polymorphisms can act as the main genes: IL1B-31TC, VEGF + 936CT and IL10-592CA.В  These genes form the main nodes in the gene network because they have the largest number of interactions with other genes, which account for 55% of all pair interactions in the gene network, which forms a predisposition to the development of UF.