{"id":10004,"date":"2020-06-29T09:36:52","date_gmt":"2020-06-29T09:36:52","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/cytokines-markers-of-oncogenesis-and-therapy-efficiency-in-chemically-induced-breast-cancer\/"},"modified":"2020-06-29T09:36:52","modified_gmt":"2020-06-29T09:36:52","slug":"cytokines-markers-of-oncogenesis-and-therapy-efficiency-in-chemically-induced-breast-cancer","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/cytokines-markers-of-oncogenesis-and-therapy-efficiency-in-chemically-induced-breast-cancer\/","title":{"rendered":"CYTOKINES &#8211; MARKERS OF ONCOGENESIS AND THERAPY EFFICIENCY IN CHEMICALLY INDUCED BREAST CANCER"},"content":{"rendered":"<p>Poster (<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/16.pdf\">download<\/a>)<br \/>\n    <br \/><a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/16.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">16<br\/><\/a><br \/>Alexandr Poveshchenko<sup>1<\/sup><br \/><sup>1<\/sup>Research Institute of Clinical andExperimental Lymphology &#8211; Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences Novosibirsk, Russia, poveshchenkoa200@mail.ru<\/p>\n<p><strong>Breast cancer was induced by the administration of n-methyl-N-nitrosourea to Wistar rats. Some animals underwent only surgical intervention or only polychemotherapy (cyclophosphamide, methotrexate, 5-ftorouracil). In some animals, both types of therapy were combined, and in a separate group, the administration of the Panagen drug, which was a fragmented DNA molecule, was added to polychemotherapy. To study the concentration of cytokines in lymph, we used the Bio-Plex Pro Rat Cytokoness 24-Plex Assay test system (Bio-Rad, USA). It was shown that in rats with breast cancer the content in the lymph and blood of most of the studied cytokines such as IL-1\u041e\u0406, IL-2, IL-4, IL-6, IL-7, IL-12, IL-13, MIP-1\u041e\u00b1, MIP-3\u041e\u00b1, RANTES, TNF-\u041e\u00b1, MCP-1 were statistically significantly higher, and IL-10 and GRO \/ KC, lower than in intact animals. Surgical removal of the tumor led to a significant decrease in the content of both pro-inflammatory and anti-inflammatory cytokines in the lymph. PCT led to a significant decrease in the content of IL-1\u041e\u0406, IL-4, IL-6, IL-7, MIP-1\u041e\u00b1, MIP-3\u041e\u00b1, RANTES in the blood serum and lymph of rats with breast cancer. <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poster (download) Alexandr Poveshchenko11Research Institute of Clinical andExperimental Lymphology &#8211; Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences Novosibirsk, Russia, poveshchenkoa200@mail.ru Breast cancer was induced by the administration of n-methyl-N-nitrosourea to Wistar rats. Some animals underwent only surgical intervention or only polychemotherapy (cyclophosphamide, methotrexate, 5-ftorouracil). In some animals, both types of therapy were combined, and in a separate group, the administration of the Panagen drug, which was a fragmented DNA molecule, was added to polychemotherapy. To study the concentration of cytokines in lymph, we used the Bio-Plex Pro Rat Cytokoness 24-Plex Assay test system (Bio-Rad, USA). It was shown that in rats with breast cancer the content in the lymph and blood of most of the studied cytokines such as IL-1\u041e\u0406, IL-2, IL-4, IL-6, IL-7, IL-12, IL-13, MIP-1\u041e\u00b1, MIP-3\u041e\u00b1, RANTES, TNF-\u041e\u00b1, MCP-1 were statistically significantly higher, and IL-10 and GRO \/ KC, lower than in intact animals. Surgical removal of the tumor led to a significant decrease in the content of both pro-inflammatory and anti-inflammatory cytokines in the lymph. PCT led to a significant decrease in the content of IL-1\u041e\u0406, IL-4, IL-6, IL-7, MIP-1\u041e\u00b1, MIP-3\u041e\u00b1, RANTES in the blood serum and lymph of rats with breast cancer.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2167],"tags":[1146,1149,1147],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10004"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=10004"}],"version-history":[{"count":0,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10004\/revisions"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=10004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=10004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=10004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}