{"id":10025,"date":"2020-06-29T09:36:52","date_gmt":"2020-06-29T09:36:52","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/gene-polymorphism-il13-in-moderate-to-severe-asthmatic-siberian-children-with-different-diseases-control\/"},"modified":"2020-07-06T06:05:20","modified_gmt":"2020-07-06T06:05:20","slug":"gene-polymorphism-il13-in-moderate-to-severe-asthmatic-siberian-children-with-different-diseases-control","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/gene-polymorphism-il13-in-moderate-to-severe-asthmatic-siberian-children-with-different-diseases-control\/","title":{"rendered":"Gene polymorphism IL13 in moderate-to-severe asthmatic Siberian children with different diseases control"},"content":{"rendered":"<p>Poster (<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/57.pdf\">download<\/a>)<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/57.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">57<br\/><\/a>\n<p>Marina Smolnikova<sup>1<\/sup>, Nina Gorbacheva<sup>2<\/sup>, Marina Malinchik<sup>3<\/sup>, Sergey Tereshchenko<sup>4<\/sup><br \/><sup>1<\/sup>Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru<br \/><sup>2<\/sup>Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, n-n-gorbacheva@yandex.ru<br \/><sup>3<\/sup>Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, seapearl1995@gmail.com<br \/><sup>4<\/sup>Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru<\/p>\n<p><strong>Multifunctional cytokines, such as IL-13, play an important role in asthma pathogenesis. Several single nucleotide polymorphisms of cytokines are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory, especially with respect to asthma severity in children. Child with moderate-to-severe asthma were divided to patients uncontrolled course of the disease (n = 107) and controlled course of the disease (n = 95). The frequency of the CT genotype IL13 (rs1800925) in patients with controlled moderate-to-severe asthma was significantly higher in comparison with control (46,2% \/ 36,6%, OR 1,51, p=0,03). Was obtained statistically significant differences in the frequency of the TT genotype between the population sample (6,7%) and the group with uncontrolled asthma (15,5%, OR 1,65, p=0,03). The results have contributed to the data on the role of polymorphisms of IL-13 into the development of asthma in children as exemplified by a European population of East Siberia, Russia.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poster (download) Marina Smolnikova1, Nina Gorbacheva2, Marina Malinchik3, Sergey Tereshchenko41Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, n-n-gorbacheva@yandex.ru3Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, seapearl1995@gmail.com4Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru Multifunctional cytokines, such as IL-13, play an important role in asthma pathogenesis. Several single nucleotide polymorphisms of cytokines are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory, especially with respect to asthma severity in children. Child with moderate-to-severe asthma were divided to patients uncontrolled course of the disease (n = 107) and controlled course of the disease (n = 95). The frequency of the CT genotype IL13 (rs1800925) in patients with controlled moderate-to-severe asthma was significantly higher in comparison with control (46,2% \/ 36,6%, OR 1,51, p=0,03). Was obtained statistically significant differences in the frequency of the TT genotype between the population sample (6,7%) and the group with uncontrolled asthma (15,5%, OR 1,65, p=0,03). The results have contributed to the data on the role of polymorphisms of IL-13 into the development of asthma in children as exemplified by a European population of East Siberia, Russia.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2165],"tags":[1229,1231,1228,1230],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10025"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=10025"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10025\/revisions"}],"predecessor-version":[{"id":12134,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10025\/revisions\/12134"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=10025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=10025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=10025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}