{"id":10114,"date":"2020-06-29T09:36:52","date_gmt":"2020-06-29T09:36:52","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/calcium-signaling-dynamics-in-single-platelets-during-optically-induced-activation\/"},"modified":"2020-07-07T15:07:44","modified_gmt":"2020-07-07T15:07:44","slug":"calcium-signaling-dynamics-in-single-platelets-during-optically-induced-activation","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/calcium-signaling-dynamics-in-single-platelets-during-optically-induced-activation\/","title":{"rendered":"Calcium Signaling Dynamics in Single Platelets during Optically-induced Activation."},"content":{"rendered":"<p>Poster (<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/212.pdf\">download<\/a>)<\/p>\n<p><a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/212.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">212<br\/><\/a><br \/>\nDarya V. Spiryova<sup>1<\/sup>, Alexander E. Moskalensky<sup>2<\/sup>, Alexei Vorob&#8217;ev<sup>3<\/sup><br \/>\n<sup>1<\/sup>NSU, gerd.raz@yandex.ru<br \/>\n<sup>2<\/sup>NSU, a.mosk@nsu.ru<br \/>\n<sup>3<\/sup>NSU, vor@nioch.nsc.ru<\/p>\n<p><em>Activation of blood platelets is the main process in normal hemostasis. Unfortunately, it also makes a great contribution to the development of cardiovascular diseases. In this work, we study activation dynamics using cytosolic calcium probe. To increase the accuracy of dynamic measurements, we present a method for optical activation of single platelets in suspension. It is achieved by the use of photolabile caged activation agonists. Futhermore, a mathematical model was developed that allows to detect individual calcium peaks and\u0412\u00a0derive their dynamic parameters.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poster (download) Darya V. Spiryova1, Alexander E. Moskalensky2, Alexei Vorob&#8217;ev3 1NSU, gerd.raz@yandex.ru 2NSU, a.mosk@nsu.ru 3NSU, vor@nioch.nsc.ru Activation of blood platelets is the main process in normal hemostasis. Unfortunately, it also makes a great contribution to the development of cardiovascular diseases. In this work, we study activation dynamics using cytosolic calcium probe. To increase the accuracy of dynamic measurements, we present a method for optical activation of single platelets in suspension. It is achieved by the use of photolabile caged activation agonists. Futhermore, a mathematical model was developed that allows to detect individual calcium peaks and\u0412\u00a0derive their dynamic parameters.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2165],"tags":[1577,1580,1579,1578],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10114"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=10114"}],"version-history":[{"count":2,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10114\/revisions"}],"predecessor-version":[{"id":12235,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10114\/revisions\/12235"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=10114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=10114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=10114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}