{"id":10116,"date":"2020-06-29T09:36:52","date_gmt":"2020-06-29T09:36:52","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/functional-roles-of-the-e3-ubiquitin-ligase-hyd-in-drosophila-tissues\/"},"modified":"2020-06-29T09:36:52","modified_gmt":"2020-06-29T09:36:52","slug":"functional-roles-of-the-e3-ubiquitin-ligase-hyd-in-drosophila-tissues","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/functional-roles-of-the-e3-ubiquitin-ligase-hyd-in-drosophila-tissues\/","title":{"rendered":"Functional Roles of the E3 Ubiquitin Ligase HYD in Drosophila Tissues"},"content":{"rendered":"<p>Poster (<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/215.pdf\">download<\/a>)<br \/>\n    <br \/><a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/215.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">215<br\/><\/a><br \/>Iuliia Galimova<sup>1<\/sup>, Natalia Vladimirovna Dorogova<sup>2<\/sup>, Svetlana Fedorova<sup>3<\/sup><br \/><sup>1<\/sup>IMCB SB RAS, Novosibirsk, Russia, galimova@mcb.nsc.ru<br \/><sup>2<\/sup>ICG SB RAS, Novosibirsk, Russia, dorogova@bionet.nsc.ru<br \/><sup>3<\/sup>ICG SB RAS, Novosibirsk, Russia, fsveta@bionet.nsc.ru<\/p>\n<p>Drosophila tumor suppressor HYD is required for the regulation of cell proliferation, growth and differentiation. HYD is involved in cell processes at different levels: it can regulate gene expression by binding to its promoters, it binds to some RNA for gene silencing and it participates in protein degradation due to its ubiquitin-ligase activity. Analysis of <em>Drosophila hyd<\/em> mutants revealed that HYD functions depend on tissue and stage of development: misexpression in larval somatic tissues causes over-proliferation, defects of meiosis and spermatid differentiation in spermatogenesis, and massive cell death with occasional germline overproliferation during oogenesis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poster (download) Iuliia Galimova1, Natalia Vladimirovna Dorogova2, Svetlana Fedorova31IMCB SB RAS, Novosibirsk, Russia, galimova@mcb.nsc.ru2ICG SB RAS, Novosibirsk, Russia, dorogova@bionet.nsc.ru3ICG SB RAS, Novosibirsk, Russia, fsveta@bionet.nsc.ru Drosophila tumor suppressor HYD is required for the regulation of cell proliferation, growth and differentiation. HYD is involved in cell processes at different levels: it can regulate gene expression by binding to its promoters, it binds to some RNA for gene silencing and it participates in protein degradation due to its ubiquitin-ligase activity. Analysis of Drosophila hyd mutants revealed that HYD functions depend on tissue and stage of development: misexpression in larval somatic tissues causes over-proliferation, defects of meiosis and spermatid differentiation in spermatogenesis, and massive cell death with occasional germline overproliferation during oogenesis.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2171],"tags":[1584,1585,1583,1582,1581],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10116"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=10116"}],"version-history":[{"count":0,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10116\/revisions"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=10116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=10116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=10116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}