{"id":10201,"date":"2020-06-29T09:36:52","date_gmt":"2020-06-29T09:36:52","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/functional-annotation-of-the-transcription-factors-from-methylotuvimicrobium-alcaliphilum-20zr\/"},"modified":"2020-06-29T09:36:52","modified_gmt":"2020-06-29T09:36:52","slug":"functional-annotation-of-the-transcription-factors-from-methylotuvimicrobium-alcaliphilum-20zr","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/06\/29\/functional-annotation-of-the-transcription-factors-from-methylotuvimicrobium-alcaliphilum-20zr\/","title":{"rendered":"Functional annotation of the transcription factors from Methylotuvimicrobium alcaliphilum 20ZR"},"content":{"rendered":"<p>Semyon K. Kolmykov<sup>1<\/sup>, Nikita V. Ivanisenko<sup>2<\/sup>, Ivan S. Evshin<sup>3<\/sup>, Mikhail Kulyashov<sup>4<\/sup>, Tamara M. Khlebodarova<sup>5<\/sup>, Ilya R. Akberdin<sup>6<\/sup><br \/><sup>1<\/sup>Institute of Computational Technologies SB RAS, kolmykovsk@gmail.com<br \/><sup>2<\/sup>FRC Institute of Cytology and Genetics SB RAS, n.ivanisenko@gmail.com<br \/><sup>3<\/sup>Institute of Computational Technologies SB RAS, ivan@biosoft.ru<br \/><sup>4<\/sup>Institute of Computational Technologies SB RAS, m.kulyashov@mail.ru<br \/><sup>5<\/sup>FRC Institute of Cytology and Genetics SB RAS, tamara@bionet.nsc.ru<br \/><sup>6<\/sup>FRC Institute of Cytology and Genetics SB RAS, akberdinir@gmail.com<\/p>\n<p>Methane is a promising carbon source for biosynthesis of biotechnologically useful compounds using aerobic methanotrophic bacteria as biocatalysts. Despite more than a century-long history of discovering and studying of methanotrophic microorganisms, knowledge of the molecular mechanisms of gene expression regulation by transcription factors in these bacteria is very limited with only a few isolated cases being published. Therefore, the identification of potential transcription factors for methanotrophic organisms and their target genes is not only a foreground fundamental problem in the research field of methanotrophy, but it is also especially relevant for the active development of biotechnological application of methane-oxidizing microorganisms. In this study a comparative genomics approach together with the structural modeling techniques were applied to reveal the TFs in the 20ZR genome and predict their target regulatory genes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Semyon K. Kolmykov1, Nikita V. Ivanisenko2, Ivan S. Evshin3, Mikhail Kulyashov4, Tamara M. Khlebodarova5, Ilya R. Akberdin61Institute of Computational Technologies SB RAS, kolmykovsk@gmail.com2FRC Institute of Cytology and Genetics SB RAS, n.ivanisenko@gmail.com3Institute of Computational Technologies SB RAS, ivan@biosoft.ru4Institute of Computational Technologies SB RAS, m.kulyashov@mail.ru5FRC Institute of Cytology and Genetics SB RAS, tamara@bionet.nsc.ru6FRC Institute of Cytology and Genetics SB RAS, akberdinir@gmail.com Methane is a promising carbon source for biosynthesis of biotechnologically useful compounds using aerobic methanotrophic bacteria as biocatalysts. Despite more than a century-long history of discovering and studying of methanotrophic microorganisms, knowledge of the molecular mechanisms of gene expression regulation by transcription factors in these bacteria is very limited with only a few isolated cases being published. Therefore, the identification of potential transcription factors for methanotrophic organisms and their target genes is not only a foreground fundamental problem in the research field of methanotrophy, but it is also especially relevant for the active development of biotechnological application of methane-oxidizing microorganisms. In this study a comparative genomics approach together with the structural modeling techniques were applied to reveal the TFs in the 20ZR genome and predict their target regulatory genes.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2171],"tags":[1869,1870,1868,1252,1589],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10201"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=10201"}],"version-history":[{"count":0,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/10201\/revisions"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=10201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=10201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=10201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}