{"id":12210,"date":"2020-07-07T09:46:03","date_gmt":"2020-07-07T09:46:03","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2020\/?p=12210"},"modified":"2020-07-07T09:49:11","modified_gmt":"2020-07-07T09:49:11","slug":"the-investigation-of-molecular-networks-involved-in-diabetes-remission-achieved-by-metabolic-bariatric-surgery","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2020\/2020\/07\/07\/the-investigation-of-molecular-networks-involved-in-diabetes-remission-achieved-by-metabolic-bariatric-surgery\/","title":{"rendered":"The Investigation of Molecular Networks Involved in Diabetes Remission Achieved by Metabolic Bariatric Surgery"},"content":{"rendered":"<p>Poster (<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/null_0.pdf\">download<\/a>)<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/wp-content\/uploads\/2020\/07\/null_0.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">null_0<br\/><\/a>\n<p>Shan Zaidi, Ancha Baranova, Ph.D.<br \/>\nDepartment of Biology, George Mason University University, Fairfax, VA, USA<\/p>\n<p>Bariatric surgery, which is primarily used to treat obesity, has shown to elicit a remission in type 2 diabetes mellitus in 40 &#8211; 50% of patients. After analysis of existing literature concerning metabolic control exerted by gut hormones, we prioritized oxyntomodulin (OXM), peptide YY (PYY), pancreatic polypeptide (PPY), ghrelin, and glucagon-like peptide 1 (GLP-1) as important<br \/>\nsoluble contributors to anti-diabetic effects of bariatric surgery. To find support for this hypothesis, analysis of diabetes-associated genetic networks was performed in Pathway Studio environment. Lowered concentrations of PYY in plasma may contribute to both type 2 diabetes and obesity. The list of molecules with levels elevated post-surgery include GLP-1 and agonists for its receptors, well-known to improve insulin and normalize glucagon defects in diabetic patients. OXM inhibits ghrelin release, thus, displaying a potential for a development as novel therapeutic. We conclude that comprehensive understanding of the post-bariatric changes in gut hormones milieu may produce novel targets for the development of novel anti-diabetic medications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poster (download) Shan Zaidi, Ancha Baranova, Ph.D. Department of Biology, George Mason University University, Fairfax, VA, USA Bariatric surgery, which is primarily used to treat obesity, has shown to elicit a remission in type 2 diabetes mellitus in 40 &#8211; 50% of patients. After analysis of existing literature concerning metabolic control exerted by gut hormones, we prioritized oxyntomodulin (OXM), peptide YY (PYY), pancreatic polypeptide (PPY), ghrelin, and glucagon-like peptide 1 (GLP-1) as important soluble contributors to anti-diabetic effects of bariatric surgery. To find support for this hypothesis, analysis of diabetes-associated genetic networks was performed in Pathway Studio environment. Lowered concentrations of PYY in plasma may contribute to both type 2 diabetes and obesity. The list of molecules with levels elevated post-surgery include GLP-1 and agonists for its receptors, well-known to improve insulin and normalize glucagon defects in diabetic patients. OXM inhibits ghrelin release, thus, displaying a potential for a development as novel therapeutic. We conclude that comprehensive understanding of the post-bariatric changes in gut hormones milieu may produce novel targets for the development of novel anti-diabetic medications.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2165],"tags":[],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/12210"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/comments?post=12210"}],"version-history":[{"count":4,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/12210\/revisions"}],"predecessor-version":[{"id":12214,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/posts\/12210\/revisions\/12214"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/media?parent=12210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/categories?post=12210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2020\/wp-json\/wp\/v2\/tags?post=12210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}