by L.N. Rachkovskaya | A.A.Smagin | V.V. Nimaev | E.E. Rachkovskiy | E.S. Yastrebova | V.P. Maltsev |
A.Yu. Letyagin | Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of
Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental
Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research
Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB
RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lymphology – Branch of the
Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | V.V. Voevodsky Institute of Chemical
Kinetics and Gorenja SB RAS, Novosibirsk, Russia | V.V. Voevodsky Institute of Chemical Kinetics and
Gorenja SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lymphology –
Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
- Morphological parameters of erythrocytes practically remain unchanged after contact with
sorbents.
(thickness, diameter, volume, surface, hemoglobin content and concentration - Within the norm, there is a slight change in the functional parameters associated with the
anion exchanger – the band 3 (B3) protein, which removes carbon dioxide from red blood cells (in the form of
the HCO3 anion, this process limits the entire oxygen exchange in the body). - Al2O3@PDMS/Ag increases all indicators (by 1.2-1.4 times) compared to the sorbent without
silver, including the ultimate extensibility of the erythrocyte membrane (MCER). The increase in parameters
relative to the original blood is slightly less (1.1 times), but the ultimate extensibility increases more
significantly (2.2 times). - The introduction of silver into the sorbent does not have a traumatic effect on the
morphofunctional parameters of erythrocytes of donor blood under perfusion conditions – all parameters of
erythrocytes are within normal limits.