{"id":13265,"date":"2021-08-25T02:23:59","date_gmt":"2021-08-25T02:23:59","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?page_id=13265"},"modified":"2022-04-15T16:17:28","modified_gmt":"2022-04-15T09:17:28","slug":"abstract-requirements","status":"publish","type":"page","link":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/abstract-requirements\/","title":{"rendered":"Abstract requirements"},"content":{"rendered":"<p><strong>\u041f\u0435\u0440\u0435\u0434 \u043e\u0442\u043f\u0440\u0430\u0432\u043a\u043e\u0439 \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u0432\u0430\u043c \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u0441\u043e\u0437\u0434\u0430\u0442\u044c \u0443\u0447\u0435\u0442\u043d\u0443\u044e \u0437\u0430\u043f\u0438\u0441\u044c \u043d\u0430 \u0441\u0430\u0439\u0442\u0435 \u043a\u043e\u043d\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0438 \u043f\u043e \u044d\u0442\u043e\u0439 \u0441\u0441\u044b\u043b\u043a\u0435: <a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wa_registration\/\">https:\/\/bgrssb.icgbio .ru\/2022\/wa_registration\/<\/a><\/strong><\/p>\n<p><span style=\"color: #ff0000;\"><strong><span class=\"VIiyi\" lang=\"en\"><span class=\"JLqJ4b ChMk0b\" data-language-for-alternatives=\"en\" data-language=\"\" data-phrase-index=\"0\" data-number-of-phrases=\"2\">\u041f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u0442\u0435\u0437\u0438\u0441\u044b \u0431\u0443\u0434\u0443\u0442 \u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043e\u043d\u043b\u0430\u0439\u043d, \u043c\u044b \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u043b\u0438 \u043c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0439 \u0440\u0430\u0437\u043c\u0435\u0440 \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u0434\u043e \u0434\u0432\u0443\u0445 \u0441\u0442\u0440\u0430\u043d\u0438\u0446. \u0422\u0435\u0437\u0438\u0441 <\/span><span class=\"JLqJ4b ChMk0b\" 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href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/03\/BGRS_2022-Conference_Template.docx\">\u0428\u0430\u0431\u043b\u043e\u043d \u0442\u0435\u0437\u0438\u0441\u043e\u0432 (docx)<\/a><\/p>\n<p>\u0422\u0435\u0437\u0438\u0441\u044b \u0434\u043e\u043b\u0436\u043d\u044b \u0431\u044b\u0442\u044c \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u044b \u043e\u043d\u043b\u0430\u0439\u043d \u0434\u043e <span style=\"color: #ff0000;\">25 \u0430\u043f\u0440\u0435\u043b\u044f<\/span> 2022\u00a0\u0433.<\/p>\n<ul>\n<li>\u0422\u0435\u0437\u0438\u0441\u044b, \u0432\u043a\u043b\u044e\u0447\u0430\u044f \u043f\u043e\u043b\u043d\u043e\u0435 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435 \u0434\u043e\u043a\u043b\u0430\u0434\u0430, \u0424\u0418\u041e \u0430\u0432\u0442\u043e\u0440\u043e\u0432, \u0438\u0445 \u043c\u0435\u0441\u0442\u043e \u0440\u0430\u0431\u043e\u0442\u044b, \u0430\u0434\u0440\u0435\u0441 \u044d\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u043e\u0439 \u043f\u043e\u0447\u0442\u044b \u0434\u043e\u043a\u043b\u0430\u0434\u0447\u0438\u043a\u0430, \u043a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u0441\u043b\u043e\u0432\u0430 \u0438 \u0442\u0435\u043a\u0441\u0442 \u0442\u0435\u0437\u0438\u0441\u043e\u0432, \u043d\u0435 \u0434\u043e\u043b\u0436\u043d\u044b \u043f\u0440\u0435\u0432\u044b\u0448\u0430\u0442\u044c \u0434\u0432\u0443\u0445 \u0441\u0442\u0440\u0430\u043d\u0438\u0446.<\/li ><\/li>\n<li>\u041d\u0430\u0437\u0432\u0430\u043d\u0438\u0435 \u043e\u0442\u0447\u0435\u0442\u0430 \u0434\u043e\u043b\u0436\u043d\u043e \u0431\u044b\u0442\u044c \u0432\u044b\u0434\u0435\u043b\u0435\u043d\u043e \u043f\u043e\u043b\u0443\u0436\u0438\u0440\u043d\u044b\u043c \u0448\u0440\u0438\u0444\u0442\u043e\u043c 14 Times New Roman.<\/li>\n<li>\u0418\u043c\u0435\u043d\u0430 \u0430\u0432\u0442\u043e\u0440\u043e\u0432 \u0440\u0430\u0437\u0434\u0435\u043b\u0435\u043d\u044b \u0437\u0430\u043f\u044f\u0442\u044b\u043c\u0438 \u0448\u0440\u0438\u0444\u0442\u043e\u043c 11 Times New Roman.<\/li>\n<li>\u041c\u0435\u0441\u0442\u043e \u0440\u0430\u0431\u043e\u0442\u044b \u0430\u0432\u0442\u043e\u0440\u043e\u0432 \u043a\u0443\u0440\u0441\u0438\u0432\u043e\u043c 9 Times New Roman.<\/li>\n<li>e-mail \u0430\u0432\u0442\u043e\u0440\u0430-\u0441\u043f\u0438\u043a\u0435\u0440\u0430 \u043a\u0443\u0440\u0441\u0438\u0432\u043e\u043c 9 Times New Roman.<\/li>\n<li>\u041a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u0441\u043b\u043e\u0432\u0430 \u043d\u0430\u0431\u0440\u0430\u043d\u044b \u043e\u0431\u044b\u0447\u043d\u044b\u043c \u0448\u0440\u0438\u0444\u0442\u043e\u043c 9 Times New Roman.<\/li>\n<li>\u0422\u0435\u043a\u0441\u0442 \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u043d\u0430\u0431\u0440\u0430\u043d \u043e\u0431\u044b\u0447\u043d\u044b\u043c \u0448\u0440\u0438\u0444\u0442\u043e\u043c 11 Times New Roman. \u041b\u0430\u0442\u0438\u043d\u0441\u043a\u0438\u0435 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u044f \u0432\u0438\u0434\u043e\u0432 \u0438 \u043e\u0431\u043e\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0433\u0435\u043d\u043e\u0432 \u0432\u044b\u0434\u0435\u043b\u0435\u043d\u044b \u043a\u0443\u0440\u0441\u0438\u0432\u043e\u043c.<\/li>\n<li>\u0420\u0430\u0437\u0434\u0435\u043b \u00ab\u0421\u0441\u044b\u043b\u043a\u0438\u00bb (\u043f\u0440\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438) \u043d\u0430\u0431\u0440\u0430\u043d \u043e\u0431\u044b\u0447\u043d\u044b\u043c \u0448\u0440\u0438\u0444\u0442\u043e\u043c 9 Times New Roman.<\/li>\n<\/ul>\n<p>\u0412\u044b \u043c\u043e\u0436\u0435\u0442\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u0448\u0430\u0431\u043b\u043e\u043d \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043f\u0440\u0438\u043c\u0435\u0440\u0430 \u0438\u043b\u0438 \u043e\u0441\u043d\u043e\u0432\u044b \u0432\u0430\u0448\u0435\u0433\u043e \u0440\u0435\u0444\u0435\u0440\u0430\u0442\u0430.<\/p>\n<p><span style=\"color: #ff0000;\"><strong>\u0418\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f \u043e \u0440\u0438\u0441\u0443\u043d\u043a\u0430\u0445 \u0432 \u0430\u043d\u043d\u043e\u0442\u0430\u0446\u0438\u0438:<\/strong><\/span><\/p>\n<p>\u0420\u0438\u0441\u0443\u043d\u043a\u0438 \u0434\u043e\u043b\u0436\u043d\u044b \u0431\u044b\u0442\u044c \u0432\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u044b \u0432 \u0444\u0430\u0439\u043b \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u0438 \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0437\u0430\u0433\u0440\u0443\u0436\u0435\u043d\u044b \u043e\u0442\u0434\u0435\u043b\u044c\u043d\u044b\u043c \u0444\u0430\u0439\u043b\u043e\u043c. \u0424\u043e\u0440\u043c\u0430\u0442\u044b: EPS, JPEG, PNG, TIFF \u0441 \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u0435\u043c 300 dpi. \u0418\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u043c\u044b\u0435 \u0432 \u0441\u0442\u0430\u0442\u044c\u0435 \u0440\u0438\u0441\u0443\u043d\u043a\u0438, \u043e\u0445\u0440\u0430\u043d\u044f\u0435\u043c\u044b\u0435 \u0437\u0430\u043a\u043e\u043d\u043e\u043c \u043e\u0431 \u0430\u0432\u0442\u043e\u0440\u0441\u043a\u043e\u043c \u043f\u0440\u0430\u0432\u0435, \u0434\u043e\u043b\u0436\u043d\u044b \u0441\u043e\u043f\u0440\u043e\u0432\u043e\u0436\u0434\u0430\u0442\u044c\u0441\u044f \u043f\u0438\u0441\u044c\u043c\u0435\u043d\u043d\u044b\u043c \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u0438\u0435\u043c \u043f\u0440\u0430\u0432\u043e\u043e\u0431\u043b\u0430\u0434\u0430\u0442\u0435\u043b\u0435\u0439 \u043d\u0430 \u0438\u0445 \u043f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u044e. \u0420\u0438\u0441\u0443\u043d\u043a\u0438 \u043d\u0435 \u0440\u0435\u0434\u0430\u043a\u0442\u0438\u0440\u0443\u044e\u0442\u0441\u044f. \u0422\u0430\u0431\u043b\u0438\u0446\u044b \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u044e\u0442\u0441\u044f \u0432 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u043e\u0439 (\u0447\u0435\u0440\u043d\u043e-\u0431\u0435\u043b\u043e\u0439) \u0446\u0432\u0435\u0442\u043e\u0432\u043e\u0439 \u0433\u0430\u043c\u043c\u0435.<\/p>\n<p><strong>\u041e\u0431\u0440\u0430\u0437\u0435\u0446:<\/strong><br \/>\n<span style=\"font-size: 8pt; font-family: times new roman, times, serif;\">DOI 10.18699\/SBB-2021-000<\/span><\/p>\n<p><span style=\"font-size: 14pt;\"><strong><span style=\"font-family: times new roman, times, serif;\">Cardiac mechanics, calcium overload and arrhythmogenesis<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\">Ivanov A.<sup>1<\/sup>*, Petrov O.<sup>1, 2<\/sup>, Sidorov L.<sup>3<br \/>\n<\/sup><\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>1 <\/sup>Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>2 <\/sup>Kurchatov Genomic Center of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>3<\/sup> Siberian Research Institute of Plant Production and Breeding \u2013 Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">* ivanov@gmail.com<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><strong>Key words:<\/strong> calcium overload, rhythm disturbances, cardiac mechanics<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Motivation and Aim<\/em>: It is well-known that Ca<sup>2+<\/sup> overload may cause cardiac arrhythmia. However, possible contribution of the mechanical factors to the arrhythmia development in Ca<sup>2+<\/sup>-overloaded cardiomyocytes has been insufficiently addressed. Earlier we have developed a mathematical model of cardiomyocyte electro-mechanical function [1] that predicted a significant role of the intra- and extracellular mechanical factors in arrhythmogenesys. Model prediction was verified in experiments on papillary muscles from the right ventricle of guinea pigs overloaded with calcium [2].<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Methods and Algorithms<\/em>: We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand formed of 90% of normal (N) cardiomyocytes and 10% of sub-critical (SC) cardiomyocytes with decreased Na<sup>+<\/sup>-K<sup>+<\/sup> pump activity. Single SC\u2011cardiomyocytes did not demonstrate spontaneous activity during isometric contractions at a reference length. Regular fiber twitches at the reference initial cell length were induced by 1 bps electrical stimulation applied at an edge of the strand. Excitation spread along the tissue via electro-diffusional cell coupling followed by cell contractions and force development in the fiber.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Results<\/em>: Mechanical interactions between N- and SC-cells in the tissue resulted in the spontaneous activity emerged in the SC\u2011zone between the regular stimuli. If the excitation wave spread from SC- to N-region, the SC-cells developed delayed after-d\u0435polarizations (DAD) that caused a slowly developing beat-to-beat decrease in the force of fiber contraction. If the excitation spread in opposite direction, DAD in the SC-cells induced reflected downward excitation waves capturing the normal region and followed by extrasystoles in the whole fiber.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Conclusion<\/em>: The results obtained in the model suggest that ectopic activity may emerge in a sub-critical myocardial region, e.g. comprising cardiomyocytes with moderately depressed N+-K+ pump, due to its mechanical interactions in the myocardial tissue. Moreover, such ectopic zone may expand by capturing normal regions in myocardium via the electro-mechanical coupling between cardiomyocytes.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Acknowledgements<\/em>: The study is supported by the Kurchatov Genomic Centre of the Institute of Cytology and Genetics, SB RAS (075-15-2019-1662).<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\">References<\/span><\/p>\n<ol>\n<li><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">Katsnelson L.B. et al. Contribution of mechanical factors to arrhythmogenesis in calcium overloaded cardiomyocytes: Model predictions and experiments. <em>Progress in Biophysics and Molecular Biology<\/em>. 2011;107(1):81-89.<\/span><\/li>\n<li><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">Lashin S.A., Matushkin Yu.G. Haploid evolutionary constructor: new features and further challenges. <em>In Silico. Biol<\/em>. 2012;11(3):125-135.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u041f\u0435\u0440\u0435\u0434 \u043e\u0442\u043f\u0440\u0430\u0432\u043a\u043e\u0439 \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u0432\u0430\u043c \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u0441\u043e\u0437\u0434\u0430\u0442\u044c \u0443\u0447\u0435\u0442\u043d\u0443\u044e \u0437\u0430\u043f\u0438\u0441\u044c \u043d\u0430 \u0441\u0430\u0439\u0442\u0435 \u043a\u043e\u043d\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0438 \u043f\u043e \u044d\u0442\u043e\u0439 \u0441\u0441\u044b\u043b\u043a\u0435: https:\/\/bgrssb.icgbio .ru\/2022\/wa_registration\/ \u041f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 \u0442\u0435\u0437\u0438\u0441\u044b \u0431\u0443\u0434\u0443\u0442 \u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u0442\u044c\u0441\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043e\u043d\u043b\u0430\u0439\u043d, \u043c\u044b \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u043b\u0438 \u043c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u044b\u0439 \u0440\u0430\u0437\u043c\u0435\u0440 \u0442\u0435\u0437\u0438\u0441\u043e\u0432 \u0434\u043e \u0434\u0432\u0443\u0445 \u0441\u0442\u0440\u0430\u043d\u0438\u0446. \u0422\u0435\u0437\u0438\u0441 \u043c\u043e\u0436\u0435\u0442 \u0432\u043a\u043b\u044e\u0447\u0430\u0442\u044c \u043b\u044e\u0431\u044b\u0435 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0435 \u0440\u0430\u0437\u0434\u0435\u043b\u044b, \u0441\u043c. \u0448\u0430\u0431\u043b\u043e\u043d \u043d\u0438\u0436\u0435. \u041a\u0430\u0436\u0434\u044b\u0439 \u0443\u0447\u0430\u0441\u0442\u043d\u0438\u043a, \u0443\u0436\u0435 \u043f\u0440\u0438\u0441\u043b\u0430\u0432\u0448\u0438\u0439 \u0442\u0435\u0437\u0438\u0441, \u043c\u043e\u0436\u0435\u0442 \u043f\u0440\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438 \u043e\u0431\u043d\u043e\u0432\u0438\u0442\u044c \u0435\u0433\u043e. \u0428\u0430\u0431\u043b\u043e\u043d \u0442\u0435\u0437\u0438\u0441\u043e\u0432 (docx) \u0422\u0435\u0437\u0438\u0441\u044b \u0434\u043e\u043b\u0436\u043d\u044b \u0431\u044b\u0442\u044c [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/pages\/13265"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/comments?post=13265"}],"version-history":[{"count":24,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/pages\/13265\/revisions"}],"predecessor-version":[{"id":14273,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/pages\/13265\/revisions\/14273"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/media?parent=13265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}