by Evgeny Ermakov | Mark Melamud | Daria Parshukova | Alexey Sizikov | Svetlana Ivanova | Georgy
\nNevinsky | Valentina Buneva | Institute of Chemical Biology and Fundamental Medicine, SB RAS,
\nNovosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk,
\nRussia | Mental Health Research Institute, Tomsk National Research Medical Center, Tomsk, Russia |
\nInstitute of Clinical Immunology, SB RAS, Novosibirsk, Russia | Mental Health Research Institute, Tomsk
\nNational Research Medical Center, Tomsk, Russia | Institute of Chemical Biology and Fundamental
\nMedicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB
\nRAS, Novosibirsk, Russia<\/p>\n
Dysregulation of cytokine networks is known to be associated with various autoimmune by Evgeny Ermakov | Mark Melamud | Daria Parshukova | Alexey Sizikov | Svetlana Ivanova | Georgy Nevinsky | Valentina Buneva | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia | Mental Health Research Institute, Tomsk National Research Medical Center, […]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[92,93,94,96,95],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15633"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/comments?post=15633"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15633\/revisions"}],"predecessor-version":[{"id":15635,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15633\/revisions\/15635"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/media?parent=15633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/categories?post=15633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/tags?post=15633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\ndiseases including multiple sclerosis (MS) and systemic lupus erythematosus (SLE). Many
\nstudies have shown changes in serum cytokine levels in MS and SLE. However, the detailed
\nchanges in serum cytokine profiles in MS and SLE are poorly understood. Besides,
\ncomparisons of cytokine profiles in these diseases have not been performed.
\nThe aim of this work was to investigate changes in the serum cytokine profiles in MS and
\nSLE patients in comparison with healthy donors in one series of experiments.
\nThe analysis was carried out in the following groups: a group of SLE patients — 60 people, a
\ngroup of MS patients — 55 people, a group of healthy donors — 36 people. The concentration
\nof 41 cytokines was determined using a MAGPIX multiplex analyzer.
\nPrincipal component analysis and discriminant least squares analysis showed that the
\ncombined multicytokine profiles of the studied groups differed. It was shown that 13, 10 and
\n22 out of 41 cytokines were changed when comparing HS vs SLE, HS vs MS, and SLE vs
\nMS, respectively.
\nThus, cytokine profiles in SLE and MS differ significantly both in comparison with healthy
\nindividuals and between these diseases. These data will help to better understand the differences in cytokine network dysregulation in MS and SLE.
\nThis work was supported by the Russian Science Foundation under grant number
\n20-15-00162.<\/p>\nErmakov_BGRS_2022- Presentation