{"id":15651,"date":"2022-06-22T10:42:39","date_gmt":"2022-06-22T03:42:39","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=15651"},"modified":"2022-09-20T10:32:44","modified_gmt":"2022-09-20T03:32:44","slug":"integrated-bioinformatics-analysis-of-the-gene-structure-of-polygenic-diseases-to-develop-effective-methods-for-their-early-prognosis","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/2022\/06\/22\/integrated-bioinformatics-analysis-of-the-gene-structure-of-polygenic-diseases-to-develop-effective-methods-for-their-early-prognosis\/","title":{"rendered":"Integrated bioinformatics analysis of the gene structure of polygenic diseases to develop effective methods for their early prognosis"},"content":{"rendered":"<p><em>by Prokofiev V. | Shevchenko A. | Konenkov V. | Research Institute of Clinical and Experimental<\/em><br \/>\n<em>Lym\u0440hology \u2013 Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk, Russia of Cytology<\/em><br \/>\n<em>and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lym\u0440hology<\/em><br \/>\n<em>\u2013 Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk, Russia of Cytology and Genetics,<\/em><br \/>\n<em>SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lym\u0440hology \u2013 Branch of<\/em><br \/>\n<em>the Institute of Cytology and Ge-netics SB RAS, Novosibirsk, Russia of Cytology and Genetics, SB RAS,<\/em><br \/>\n<em>Novosibirsk, Russia<\/em><\/p>\n<p>It is impossible to imagine modern medical genetics of polygenic human diseases without<br \/>\nthe widespread use of intelligent analysis and machine learning methods, in particular, such<br \/>\nas simulation of stochastic processes, MDR analysis, bioinformatic analysis of complex<br \/>\nbiological networks based on graph theory, which allow replacing the original, largely<br \/>\nstochastic, object with its image &#8212; a mathematical model with further study of this model<br \/>\nusing computer implemented computational logic algorithms or heuristic. In connection<br \/>\nwith the above, it is very relevant to conduct comparative clinical and genetic studies with<br \/>\nthe analysis of combined genotypes in combination with various variants of mathematical<br \/>\nmodeling, the results of which can become the basis for the development of fundamentally<br \/>\nnew ways to predict the development of socially significant human diseases, their early<br \/>\ndiagnosis and prevention.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/06\/Poster-2_Prokofiev-V_Abstracts2_BGRS-2022.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">Poster 2_Prokofiev V_Abstracts2_BGRS-2022<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Prokofiev V. | Shevchenko A. | Konenkov V. | Research Institute of Clinical and Experimental Lym\u0440hology \u2013 Branch of the Institute of Cytology and Ge-netics SB RAS, Novosibirsk, Russia of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Research Institute of Clinical and Experimental Lym\u0440hology \u2013 Branch of the Institute of Cytology and Ge-netics [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[100,108,101,102,109,110,111],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15651"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/comments?post=15651"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15651\/revisions"}],"predecessor-version":[{"id":15653,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/15651\/revisions\/15653"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/media?parent=15651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/categories?post=15651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/tags?post=15651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}