{"id":16223,"date":"2022-07-07T11:18:18","date_gmt":"2022-07-07T04:18:18","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=16223"},"modified":"2022-09-20T10:31:54","modified_gmt":"2022-09-20T03:31:54","slug":"re-analysis-of-dna-methylation-data-from-tuberculosisinfected-individuals-with-a-focus-on-target-genes","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/2022\/07\/07\/re-analysis-of-dna-methylation-data-from-tuberculosisinfected-individuals-with-a-focus-on-target-genes\/","title":{"rendered":"Re-analysis of DNA methylation data from tuberculosisinfected individuals with a focus on target genes"},"content":{"rendered":"<p><em>by Babushkina Nadezhda | Bragina Elena | Gonchrova Irina | Markov Anton | Kucher Aksana | Nazarenko<\/em><br \/>\n<em>Maria | Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk,<\/em><br \/>\n<em>Russia<\/em><\/p>\n<p>Along with the structural variability of the genome, epigenetic modifications can be<br \/>\nsignificant for susceptibility to various, including infectious diseases. The aim of this study<br \/>\nwas to re-analyze the differential methylation of genes (DMG), for which associations with<br \/>\ntuberculosis and its pathogenetically significant features were previously established, as<br \/>\nwell as for those of interest from the point of view of studying the phenomenon of reverse<br \/>\ncomorbidity of asthma and tuberculosis.<br \/>\nWe showed, that DNA methylation is important in TB development. The differential value of<br \/>\nDNA methylation of 13 target genes associated with TB, as well as the localization of these<br \/>\nsites in the binding regions of transcription factors involved in the development of the<br \/>\nimmune response to infection, confirm the involvement of protein products of target genes<br \/>\nin the pathogenesis of TB.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/07\/BGRS-SB-2022-TB.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">BGRS-SB-2022-TB<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Babushkina Nadezhda | Bragina Elena | Gonchrova Irina | Markov Anton | Kucher Aksana | Nazarenko Maria | Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk, Russia Along with the structural variability of the genome, epigenetic modifications can be significant for susceptibility to various, including infectious diseases. The aim of [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[26,406],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/16223"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/comments?post=16223"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/16223\/revisions"}],"predecessor-version":[{"id":16225,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/posts\/16223\/revisions\/16225"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/media?parent=16223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/categories?post=16223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/ru\/wp-json\/wp\/v2\/tags?post=16223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}