{"id":13265,"date":"2021-08-25T02:23:59","date_gmt":"2021-08-25T02:23:59","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?page_id=13265"},"modified":"2022-04-15T16:17:28","modified_gmt":"2022-04-15T09:17:28","slug":"abstract-requirements","status":"publish","type":"page","link":"https:\/\/bgrssb.icgbio.ru\/2022\/abstract-requirements\/","title":{"rendered":"Abstract requirements"},"content":{"rendered":"<p><strong>Before submitting your abstract, you need to create an account on the conference website using this link: <a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wa_registration\/\">https:\/\/bgrssb.icgbio.ru\/2022\/wa_registration\/<\/a><\/strong><\/p>\n<p><span style=\"color: #ff0000;\"><strong><span class=\"VIiyi\" lang=\"en\"><span class=\"JLqJ4b ChMk0b\" data-language-for-alternatives=\"en\" data-language-to-translate-into=\"ru\" data-phrase-index=\"0\" data-number-of-phrases=\"2\">Since abstracts will only be published online, we have increased the maximum abstract size to two pages.<\/span> Abstract<span class=\"JLqJ4b ChMk0b\" data-language-for-alternatives=\"en\" data-language-to-translate-into=\"ru\" data-phrase-index=\"1\" data-number-of-phrases=\"2\"> may include any necessary sections, see the template below.<\/span><\/span> <\/strong><\/span><\/p>\n<p><strong><span style=\"color: #ff0000;\">Every participant who already sent the abstract can update it if necessary.<\/span><\/strong><\/p>\n<p><a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/03\/BGRS_2022-Conference_Template.docx\">Abstract template (docx)<\/a><\/p>\n<p>The abstracts must be submitted online before <span style=\"color: #ff0000;\">April, 25,<\/span> 2022.<\/p>\n<ul>\n<li>The abstracts, including the full title of the report, full name of the authors, their place of work, e-mail address of the speaker, key words and the text of the abstract should not exceed two pages.<\/li>\n<li>The title of the report should be in bold 14 Times New Roman.<\/li>\n<li>Authors\u2018 names separated by commas in 11 Times New Roman.<\/li>\n<li>Place of work of the authors in italic font 9 Times New Roman.<\/li>\n<li>e-mail of the author-speaker in italic font 9 Times New Roman.<\/li>\n<li>Key words in regular font 9 Times New Roman.<\/li>\n<li>The text of the abstracts in regular font 11 Times New Roman. Latin names of species and gene designations are italicized.<\/li>\n<li>References section (if required) in regular font 9 Times New Roman.<\/li>\n<\/ul>\n<p>You can use the template as an example or base of your abstract.<\/p>\n<p><span style=\"color: #ff0000;\"><strong>The information about figures in the abstract:<\/strong><\/span><\/p>\n<p>Figures must be inserted in the abstract file and additionally uploaded as separate file. Formats: EPS, JPEG, PNG, TIFF with a resolution of 300 dpi. Figures used in the article, protected by copyright law, must be accompanied by written permission from the copyright holders for their publication. Figures will not be edited. Tables are accepted with a standard (black and white) color scheme.<\/p>\n<p><strong>Sample:<\/strong><\/p>\n<p><span style=\"font-size: 8pt; font-family: times new roman, times, serif;\">DOI 10.18699\/SBB-2021-000<\/span><\/p>\n<p><span style=\"font-size: 14pt;\"><strong><span style=\"font-family: times new roman, times, serif;\">Cardiac mechanics, calcium overload and arrhythmogenesis<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\">Ivanov A.<sup>1<\/sup>*, Petrov O.<sup>1, 2<\/sup>, Sidorov L.<sup>3<br \/>\n<\/sup><\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>1 <\/sup>Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>2 <\/sup>Kurchatov Genomic Center of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><sup>3<\/sup> Siberian Research Institute of Plant Production and Breeding \u2013 Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<br \/>\n<\/span><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">* ivanov@gmail.com<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\"><strong>Key words:<\/strong> calcium overload, rhythm disturbances, cardiac mechanics<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Motivation and Aim<\/em>: It is well-known that Ca<sup>2+<\/sup> overload may cause cardiac arrhythmia. However, possible contribution of the mechanical factors to the arrhythmia development in Ca<sup>2+<\/sup>-overloaded cardiomyocytes has been insufficiently addressed. Earlier we have developed a mathematical model of cardiomyocyte electro-mechanical function [1] that predicted a significant role of the intra- and extracellular mechanical factors in arrhythmogenesys. Model prediction was verified in experiments on papillary muscles from the right ventricle of guinea pigs overloaded with calcium [2].<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Methods and Algorithms<\/em>: We utilized the cellular model to study effects of the electromechanical coupling between cardiomyocytes in a 1D heterogeneous muscle strand formed of 90% of normal (N) cardiomyocytes and 10% of sub-critical (SC) cardiomyocytes with decreased Na<sup>+<\/sup>-K<sup>+<\/sup> pump activity. Single SC\u2011cardiomyocytes did not demonstrate spontaneous activity during isometric contractions at a reference length. Regular fiber twitches at the reference initial cell length were induced by 1 bps electrical stimulation applied at an edge of the strand. Excitation spread along the tissue via electro-diffusional cell coupling followed by cell contractions and force development in the fiber.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Results<\/em>: Mechanical interactions between N- and SC-cells in the tissue resulted in the spontaneous activity emerged in the SC\u2011zone between the regular stimuli. If the excitation wave spread from SC- to N-region, the SC-cells developed delayed after-d\u0435polarizations (DAD) that caused a slowly developing beat-to-beat decrease in the force of fiber contraction. If the excitation spread in opposite direction, DAD in the SC-cells induced reflected downward excitation waves capturing the normal region and followed by extrasystoles in the whole fiber.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Conclusion<\/em>: The results obtained in the model suggest that ectopic activity may emerge in a sub-critical myocardial region, e.g. comprising cardiomyocytes with moderately depressed N+-K+ pump, due to its mechanical interactions in the myocardial tissue. Moreover, such ectopic zone may expand by capturing normal regions in myocardium via the electro-mechanical coupling between cardiomyocytes.<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\"><em>Acknowledgements<\/em>: The study is supported by the Kurchatov Genomic Centre of the Institute of Cytology and Genetics, SB RAS (075-15-2019-1662).<\/span><\/p>\n<p><span style=\"font-family: times new roman, times, serif; font-size: 11pt;\">References<\/span><\/p>\n<ol>\n<li><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">Katsnelson L.B. et al. Contribution of mechanical factors to arrhythmogenesis in calcium overloaded cardiomyocytes: Model predictions and experiments. <em>Progress in Biophysics and Molecular Biology<\/em>. 2011;107(1):81-89.<\/span><\/li>\n<li><span style=\"font-family: times new roman, times, serif; font-size: 9pt;\">Lashin S.A., Matushkin Yu.G. Haploid evolutionary constructor: new features and further challenges. <em>In Silico. Biol<\/em>. 2012;11(3):125-135.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Before submitting your abstract, you need to create an account on the conference website using this link: https:\/\/bgrssb.icgbio.ru\/2022\/wa_registration\/ Since abstracts will only be published online, we have increased the maximum abstract size to two pages. Abstract may include any necessary sections, see the template below. Every participant who already sent the abstract can update it [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/pages\/13265"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=13265"}],"version-history":[{"count":24,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/pages\/13265\/revisions"}],"predecessor-version":[{"id":14273,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/pages\/13265\/revisions\/14273"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=13265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}