{"id":15708,"date":"2022-06-24T13:02:39","date_gmt":"2022-06-24T06:02:39","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=15708"},"modified":"2022-09-20T10:32:44","modified_gmt":"2022-09-20T03:32:44","slug":"transcription-factor-binding-sites-data-integration-stable-identifiers-and-incremental-builds","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/2022\/06\/24\/transcription-factor-binding-sites-data-integration-stable-identifiers-and-incremental-builds\/","title":{"rendered":"Transcription factor binding sites: data integration, stable identifiers and incremental builds"},"content":{"rendered":"<p><em>by Kolmykov Semyon | Kondrakhin Yury | Sharipov Ruslan | Yevshin Ivan | Ryabova Anna | Kolpakov<\/em><br \/>\n<em>Fedor | Sirius University of Science and Technology, Sochi, 354340, Russian Federation | Federal<\/em><br \/>\n<em>Research Center for Information and Computational Technologies, Novosibirsk, 630090, Russian<\/em><br \/>\n<em>Federation | Novosibirsk State University, 630090, Russian Federation | BIOSOFT.RU, LLC, Novosibirsk, 630090, Russian Federation\u00a0<\/em><\/p>\n<p>The report describes the modifications of the previously developed algorithm for metaanalysis of ChIP-seq datasets through the rank aggregation approach (METARA). It<br \/>\nevaluates the quality (or reliability) of each meta-cluster by calculation of the rank aggregation score.<br \/>\nThere are two main reasons for creating IMETARA (incremental METARA):<br \/>\n1) to significantly reduce the run time of meta-cluster building;<br \/>\n2) to introduce stable identifiers for each meta-cluster, which will allow researchers to<br \/>\nrefer directly to the meta-clusters of TF binding sites, as they currently refer to SNP.<br \/>\nThus, IMETARA only recalculates the rank aggregation scores for existing meta-clusters and<br \/>\nadds novel meta-clusters and gives stable IDs, when there are new ChIP-seq experiments<br \/>\nare added to the ChIP-seq data collection already stored in GTRD.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/06\/BGRS_SB-2022_SKolmykov_slides.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">BGRS_SB-2022_SKolmykov_slides<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Kolmykov Semyon | Kondrakhin Yury | Sharipov Ruslan | Yevshin Ivan | Ryabova Anna | Kolpakov Fedor | Sirius University of Science and Technology, Sochi, 354340, Russian Federation | Federal Research Center for Information and Computational Technologies, Novosibirsk, 630090, Russian Federation | Novosibirsk State University, 630090, Russian Federation | BIOSOFT.RU, LLC, Novosibirsk, 630090, Russian [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5,1],"tags":[168,169,170,171],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15708"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=15708"}],"version-history":[{"count":2,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15708\/revisions"}],"predecessor-version":[{"id":15711,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15708\/revisions\/15711"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=15708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/categories?post=15708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/tags?post=15708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}