{"id":15901,"date":"2022-06-29T11:25:41","date_gmt":"2022-06-29T04:25:41","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=15901"},"modified":"2022-09-20T10:32:15","modified_gmt":"2022-09-20T03:32:15","slug":"autoimmune-effect-of-antibodies-against-the-sars-cov-2-nucleoprotein","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/2022\/06\/29\/autoimmune-effect-of-antibodies-against-the-sars-cov-2-nucleoprotein\/","title":{"rendered":"Autoimmune effect of antibodies against the SARS-Cov-2 nucleoprotein"},"content":{"rendered":"<p><em>by Daria Matyushkina | Varvara Shokina | Polina Tikhonova | Valentin Manuvera | Daria Kharlampieva |<\/em><br \/>\n<em>Vasily Lazarev | Anna Varizhuk | Tatiana Vedekhina | Alexander Pavlenko | Georgij Arapidi | Vadim<\/em><br \/>\n<em>Govorun | Federal Research and Clinical Center of Physical-Chemical Medicine; Moscow Institute of Physics and Technology (National Research University)<\/em><br \/>\n<em>| Scientific Research Institute for Systems Biology and Medicine\u00a0<\/em><\/p>\n<p>COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically<br \/>\naffect our daily life. New strains appear, and the severity of the course of the disease itself<br \/>\nseems to be decreasing, but even people who have been ill on an outpatient basis suffer<br \/>\npost-COVID consequences. Partly, it is associated with the autoimmune reactions, so<br \/>\ndebates about the development of new vaccines and the need for vaccination\/revaccination<br \/>\ncontinue. In this study we performed an analysis of the antibody response of patients with<br \/>\nCOVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array<br \/>\nand western blot with analysis of correlations between antibody titer, disease severity, and<br \/>\ncomplications. We have shown that the presence of IgG antibodies to the nucleoprotein can<br \/>\ndeteriorate the course of the disease, induce multiple direct COVID-19 symptoms, and<br \/>\ncontribute to long-term post-covid symptoms. We analyzed the cross reactivity of antibodies<br \/>\nto SARS-CoV-2 with own human proteins and showed that antibodies to the nucleocapsid<br \/>\nprotein can bind to human proteins. In accordance with the possibility of HLA presentation,<br \/>\nthe main possible targets of the autoantibodies were identified. People with HLA alleles<br \/>\nA01:01; A26:01; B39:01; B15:01 are most susceptible to the development of autoimmune<br \/>\nprocesses after COVID-19.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/06\/Matyushkina-D..pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">Matyushkina D.<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Daria Matyushkina | Varvara Shokina | Polina Tikhonova | Valentin Manuvera | Daria Kharlampieva | Vasily Lazarev | Anna Varizhuk | Tatiana Vedekhina | Alexander Pavlenko | Georgij Arapidi | Vadim Govorun | Federal Research and Clinical Center of Physical-Chemical Medicine; Moscow Institute of Physics and Technology (National Research University) | Scientific Research Institute [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[259,260,256,88,258,257],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15901"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=15901"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15901\/revisions"}],"predecessor-version":[{"id":15903,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/15901\/revisions\/15903"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=15901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/categories?post=15901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/tags?post=15901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}