{"id":16034,"date":"2022-07-03T11:50:05","date_gmt":"2022-07-03T04:50:05","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=16034"},"modified":"2022-09-20T10:32:15","modified_gmt":"2022-09-20T03:32:15","slug":"loci-associated-with-negative-heterosis-for-viability-and-meat-productivity-in-interspecies-sheep-hybrids","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/2022\/07\/03\/loci-associated-with-negative-heterosis-for-viability-and-meat-productivity-in-interspecies-sheep-hybrids\/","title":{"rendered":"Loci associated with negative heterosis for viability and meat productivity in interspecies sheep hybrids"},"content":{"rendered":"<p><em>by Alexander S. Zlobin | Natalia A. Volkova | Natalia A. Zinovieva | Baylar S. Iolchiev | Vugar A. Bagirov |<\/em><br \/>\n<em>Pavel M. Borodin | Tatiana I. Aksenovich | Yakov A. Tsepilov | Kurchatov Genomic Center of the Institute<\/em><br \/>\n<em>of Cytology and Genetics, SB RAS, Novosibirsk, Russia | L.K. Ernst Federal Science Center for Animal<\/em><br \/>\n<em>Husbandry, Dubrovitsy, Moscow Region, Russia |\u00a0Institute of Cytology and Genetics, SB RAS,<\/em><br \/>\n<em>Novosibirsk, Russia\u00a0<\/em><\/p>\n<p>The modern market demands the animal breeds or breed types characterized by good<br \/>\nviability, high growth rate and ability to effectively use feed. One of the way to improve the<br \/>\nexisting breeds is obtaining of breed hybrids. Hybrids are expected to have the increasing of<br \/>\nthe economically important traits because of mixing the genetic contributions of its parents.<br \/>\nHowever, earlier for hybrids of romanovskaya sheep and argali (Ovis ammon) negative<br \/>\nheterosis was shown for meat productivity traits and viability. In this work, we aimed to find<br \/>\ngenetic loci associated with negative heterosis in these hybrids.<br \/>\nIn total we have studied 87 backcross of romanovskaya x argali. Viability information was<br \/>\navailable for four time-points after animal birth (6 days, 42 days, 3 months, 6 month). We<br \/>\nused four indexes related to meat productivity (compactness, shortlegged, length and<br \/>\ncumulative) measured at 42 days after animal birth. We used Cox regression for viability<br \/>\nGWAS analysis and linear model for GWAS analysis of meat productivity traits. For each of<br \/>\nthe trait we used additive and three non-additive models (dominant, recessive,<br \/>\noverdominant). As covariates, we used sex, number of fetuses, last time interval with<br \/>\navailable phenotype information, two first genetical principal components of kinship matrix<br \/>\nand PRS (Polygenic risk score) for SNPs shown as associated with mortality.<br \/>\nThe results can be useful for further association studies and preliminary estimation of<br \/>\ngenetic variability for economically important traits in different sheep breeds.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/07\/BGRS2022_hybrids.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">BGRS2022_hybrids<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Alexander S. Zlobin | Natalia A. Volkova | Natalia A. Zinovieva | Baylar S. Iolchiev | Vugar A. Bagirov | Pavel M. Borodin | Tatiana I. Aksenovich | Yakov A. Tsepilov | Kurchatov Genomic Center of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | L.K. Ernst Federal Science Center for Animal [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[11],"tags":[321,322,323,324,325],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16034"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=16034"}],"version-history":[{"count":1,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16034\/revisions"}],"predecessor-version":[{"id":16036,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16034\/revisions\/16036"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=16034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/categories?post=16034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/tags?post=16034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}