{"id":16149,"date":"2022-07-05T13:41:21","date_gmt":"2022-07-05T06:41:21","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=16149"},"modified":"2022-09-20T10:31:55","modified_gmt":"2022-09-20T03:31:55","slug":"comprehensive-biomarkers-of-accelerated-aging-and-mortality-risk-in-end-stage-renal-disease","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/2022\/07\/05\/comprehensive-biomarkers-of-accelerated-aging-and-mortality-risk-in-end-stage-renal-disease\/","title":{"rendered":"Comprehensive biomarkers of accelerated aging and mortality risk in end-stage renal disease"},"content":{"rendered":"<p><em>by Elena Kondakova | Igor Yusipov | Nadezhda Lobanova | Mikhail Ivanchenko | Maria Vedunova |<\/em><br \/>\n<em>Institute of Biology and Biomedicine, Lobachevsky University, Nizhny Novgorod, Russia | Institute of<\/em><br \/>\n<em>Information Technologies, Mathematics and Mechanics, Lobachevsky University, Nizhny Novgorod,<\/em><br \/>\n<em>Russia | Institute of Biology and Biomedicine, Lobachevsky University, Nizhny Novgorod, Russia |<\/em><br \/>\n<em>Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky University, Nizhny<\/em><br \/>\n<em>Novgorod, Russia | Institute of Biology and Biomedicine, Lobachevsky University, Nizhny Novgorod,<\/em><br \/>\n<em>Russia<\/em><\/p>\n<p>Accelerated aging is a process associated with the accumulation of harmful changes in the<br \/>\nbody and an increased risk of disease and death. Despite advances in the treatment of<br \/>\nchronic kidney disease and optimization of the hemodialysis process in end-stage renal<br \/>\ndisease (ESRD), morbidity and mortality in this group of people remain constantly high.<br \/>\nIdentification of markers of accelerated aging and mortality risk will allow finding possible<br \/>\ninterventions to increase the duration and improve the quality of life of patients. The study<br \/>\nparticipants were men and women aged 24 to 89 years. Of the 420 participants in the study,<br \/>\ntwo groups were selected (patients with ESRD and controls) with the maximum match in<br \/>\nage and gender. We demonstrated that ESRD is associated with the significant acceleration<br \/>\nof biological age compared with the control group. There was a statistically significant<br \/>\nincrease in the content of all biomarkers (FGF21 GDF15, CXCL9) presented in the ESRD<br \/>\ngroup compared to the controls. We analyzed patients in terms of one-year survival and<br \/>\ndividing the group of patients according to the disease outcome showed a significant<br \/>\nincrease in the FGF21 content in the ESRD group with unfavorable one-year survival<br \/>\nprognoses. We developed an estimator of biological age based on the blood concentration of<br \/>\nthree biomarkers: Age-Estimation Clock. When analyzing the one-year survival prognosis, a<br \/>\nsignificant increase in Age-Estimation Clock was found in the group of deceased patients.<br \/>\nThese findings, together with the evidence on the high prognostic value of FGF21 as a risk<br \/>\nof mortality factor in patients with ESRD, opens up the possibility of further improvement of<br \/>\nthe model\u2019s predictive value and the risk group identification.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/07\/BGRS-Kondakova.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">BGRS Kondakova<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Elena Kondakova | Igor Yusipov | Nadezhda Lobanova | Mikhail Ivanchenko | Maria Vedunova | Institute of Biology and Biomedicine, Lobachevsky University, Nizhny Novgorod, Russia | Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky University, Nizhny Novgorod, Russia | Institute of Biology and Biomedicine, Lobachevsky University, Nizhny Novgorod, Russia | Institute of Information Technologies, [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[383,384,385,44,386],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16149"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=16149"}],"version-history":[{"count":2,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16149\/revisions"}],"predecessor-version":[{"id":18085,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16149\/revisions\/18085"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=16149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/categories?post=16149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/tags?post=16149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}