{"id":16226,"date":"2022-07-07T11:20:32","date_gmt":"2022-07-07T04:20:32","guid":{"rendered":"https:\/\/bgrssb.icgbio.ru\/2022\/?p=16226"},"modified":"2022-09-20T10:31:54","modified_gmt":"2022-09-20T03:31:54","slug":"natural-selection-against-insufficiency-in-sarcomeric-proteins-reduces-the-risks-of-cardiomyopathy-in-humans-versus-the-nearest-wild-congeners-chimpanzees","status":"publish","type":"post","link":"https:\/\/bgrssb.icgbio.ru\/2022\/2022\/07\/07\/natural-selection-against-insufficiency-in-sarcomeric-proteins-reduces-the-risks-of-cardiomyopathy-in-humans-versus-the-nearest-wild-congeners-chimpanzees\/","title":{"rendered":"Natural selection against insufficiency in sarcomeric proteins reduces the risks of cardiomyopathy in humans versus the nearest wild congeners (chimpanzees)"},"content":{"rendered":"<p><em>by Karina Zolotareva | Irina Chadaeva | Bato Khandaev | Anton Bogomolov | Dmitry Oshchepkov | Maria<\/em><br \/>\n<em>Nazarenko | Mikhail Ponomarenko | Nikolay Kolchanov | Institute of Cytology and Genetics, SB RAS,<\/em><br \/>\n<em>Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of<\/em><br \/>\n<em>Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS,<\/em><br \/>\n<em>Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of<\/em><br \/>\n<em>Medical Genetics, Tomsk National Research Medical Center, Tomsk, Russia | Institute of Cytology and<\/em><br \/>\n<em>Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia<\/em><\/p>\n<p><strong>Motivation and Aim<\/strong>: Cardiomyopathy is the most common cause of spontaneous death in<br \/>\nchimpanzees, who is our nearest wild congeners [1].<br \/>\n<strong>Methods and Algorithms<\/strong>: Using our previously published Web service<br \/>\nSNP_TATA_Comparator, we analyzed single-nucleotide polymorphisms (SNPs) within 70 bp<br \/>\nproximal promoters of eight human sarcomeric protein genes, as shown in Figure.<br \/>\n<strong>Results<\/strong>: After analyzing 637 such SNPs, we identified 92 and 54 candidate SNP markers for<br \/>\nworsened and relieved, respectively, hypertrophic cardiomyopathy (HC), as susceptibility to<br \/>\nheart failure. Among them, 84 and 62 candidate SNP markers overexpressing and<br \/>\nunderexpressing, respectively, these genes as natural selection against the human<br \/>\nsarcomeric protein deficit, being resistance to heart failure. This simultaneity of<br \/>\nsusceptibility and resistance to heart failure means disruptive natural selection of the<br \/>\nconsidered human genes as if humans could exposed self-domestication that is debatable.<br \/>\nWe tested this using public 5591 differentially expressed gene (DEGs) of domestic versus<br \/>\nwild animals. In the domestic animals, the overexpressed sarcomeric protein DEGs<br \/>\ndominated the underexpressed ones (29 vs 15, respectively) just as natural selection against<br \/>\nthe human sarcomeric protein deficiency. Amounts of the domestic animal DEGs<br \/>\ncorresponding to relieved HC condition in humans surpassed those in wild animals (8 vs 1).<br \/>\n<strong>Conclusion<\/strong>: Thus, natural selection against the sarcomeric proteins deficit reduces the risks of cardiomyopathy in humans versus chimpanzees as the nearest wild congeners, for whom<br \/>\nit is the most common cause of spontaneous death.<br \/>\n<strong>Acknowledgements<\/strong>: We thank the Multi-Access Center \u201cBioinformatics\u201d for the use of<br \/>\ncomputational resources supported by Russian government project FWNR-2022-0020.<\/p>\n<a href=\"https:\/\/bgrssb.icgbio.ru\/2022\/wp-content\/uploads\/sites\/3\/2022\/07\/Zolotareva_Poster_6-slades_BGRS_2022.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\"  data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">Zolotareva_Poster_(6-slades)_BGRS_2022<br\/><\/a>\n","protected":false},"excerpt":{"rendered":"<p>by Karina Zolotareva | Irina Chadaeva | Bato Khandaev | Anton Bogomolov | Dmitry Oshchepkov | Maria Nazarenko | Mikhail Ponomarenko | Nikolay Kolchanov | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | [&hellip;]<\/p>\n","protected":false},"author":3967,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[409,410,411,412,413,166,414,415,416,407,408],"_links":{"self":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16226"}],"collection":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/users\/3967"}],"replies":[{"embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/comments?post=16226"}],"version-history":[{"count":2,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16226\/revisions"}],"predecessor-version":[{"id":18078,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/posts\/16226\/revisions\/18078"}],"wp:attachment":[{"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/media?parent=16226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/categories?post=16226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bgrssb.icgbio.ru\/2022\/wp-json\/wp\/v2\/tags?post=16226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}