Poster (download)
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Pivkina A.V.1, Rachkovskaya L.N.2, Nimaev V.V.3, Smagin A.A.4, Shurlygina A.V.5, Rachkovsky E.E.6, Yastrebova E.S.7, Korolev M.A.8, Maltsev V.P.9, Letyagin A.Yu.10
1Novosibirsk state university, a.pivkina@g.nsu.ru
2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, noolit@niikel.ru
3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, nimaev@gmail.com
4Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, asa57@ngs.ru
5Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, anna_v_s@mail.ru
6Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, noolit@niikel.ru
7V.V. Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, maltsev@kinetics.nsc.ru
8Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, kormax@bk.ru
9V.V. Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, maltsev@kinetics.nsc.ru
10Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, letyagin-andrey@yandex.ru
The use of solid porous materials in the composition of drugs promotes the delivery of active substances to the zone of their therapeutic effect and allows the body to be sanitized against various harmful substances by means of efferent detoxification methods. It is important to evaluate the safety of solid porous bodies in relation to the biological tissues of the body. This can be done using scanning flow cytometry. The biological properties of the sorbent were evaluated by its effect on red blood cells by scanning flow cytometry with determination of the functional and morphological parameters of red blood cells. The study showed that the aluminum-silicon sorbent minimally changes the morphological parameters, the ratio of stiffness to the plasticity of the membrane, and does not critically reduce the number of strip 3 proteins in red blood cells responsible for anionic cell exchange.