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Masnavieva Liudmila1, Kudaeva Irina2, Chistova Nadezhda3
1East-Siberian Institute of Medical and Ecological Research, Masnavieva_luda@mail.ru
2East-Siberian Institute of Medical and Ecological Research, Kudaeva_Irina@mail.ru
3East-Siberian Institute of Medical and Ecological Research, chist1nad2pavl3@gmail.com
Changes in the activity of lipid peroxidation processes are observed when exposed to vibration, as well as metabolic syndrome and type 2 diabetes, which are characterized by metabolic disorders. This study is devoted to the assessment of atherogenic and oxidative processes in individuals with hand-arm vibration syndrome in combination with metabolic disorders. We examined the levels of cholesterol, cholesterol in high and low density lipoproteins, oxidized low density lipoproteins, antibodies to them and the thiol status in 59 men with hand-arm vibration syndrome, in 73 people with vibrational disease in combination with metabolic syndrome and in 35 individuals with hand-arm vibration syndrome and type 2 diabetes. It was found that the average value of total cholesterol was higher than the reference level in all groups. A decrease in cholesterol in high density lipoproteins and an increase in cholesterol in low density lipoproteins have been observed in individuals with metabolic disorders. Levels of oxidized low-density lipoproteins and antibodies to them were increased in all groups. Correlation existed between the level of total cholesterol and cholesterol in low density lipoprotein, between the content of oxidized low density lipoproteins and total cholesterol, between the concentration of oxidized low density lipoproteins and cholesterol in low density lipoprotein in all groups. The correlation between the cholesterol level in high lipoproteins and thiol status was disrupted in patients with hand-arm vibration syndrome and metabolic disorders.