Poster (download)
[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/217.pdf”]
Aleksey Mukhin1, Victor Levitsky2, Dmitriy Y. Oschepkov3, Sergey A. Lashin4
1Institute Cytology and Genetics SB RAS Novosibirsk, Russia, mukhin@bionet.nsc.ru
2Institute Cytology and Genetics SB RAS, levitsky@bionet.nsc.ru
3Institute Cytology and Genetics SB RAS, diman@bionet.nsc.ru
4Institute Cytology and Genetics SB RAS, lashin@bionet.nsc.ru
Regulation of eukaryotic gene expression is controlled by specific regulatory proteins transcription factors. Binding sites of transcription factors are called motifs. Conventionally, genome-wide annotation of motifs performed with chromatin immunoprecipitation followed by massive sequencing (ChIP-seq) approach. The term composite element (CE) implied two closely located and frequently occurred in genomic DNA motifs. CEs contain two overlapping or spacing motifs. Earlier we proposed Motif Co-Occurrence Tool (MCOT) package that is capable of (a) predicting CEs with both overlapping and spacing of motifs in a single ChIP-seq dataset; (b) all predicted CEs were classified by conservation of both participant motifs. This work presents a web interface WebMCOT for MCOT package