Natalya Sitnikova1, Anastasiya Solovieva2, Tatiana N. Pozmogova3, Yuri A. Vorotnikov4, Svetlana M. Miroshnichenko5, Michael A. Shestopalov6, Kushnarenko O. Andrey7
1RICEL – Branch of ICG SB RAS, kiara112@mail.ru
2RICEL – Branch of ICG SB RAS, solovey_ao@mail.ru
3RICEL – Branch of ICG SB RAS, Tnp_post@mail.ru
4NIIC SB RAS, RICEL – Branch of ICG SB RAS, matashandu@gmail.com
5RICEL – Branch of ICG SB RAS, svmiro@yandex.ru
6RICEL – Branch of ICG SB RAS, NIIC SB RAS, shtopy@niic.nsc.ru
7RICEL- Branch of ICG SB RAS, aokushnarenko@mail.ru
Photodynamic therapy (PDT) is one of the most promising methods of treating cancer, although it has it’s limitations due to applying visible light sources with limited exposure depth. This allows the method to be used only for superficial tumors treatment and can damage healthy cells as well. To increase the efficiency of the method for treatment of deep lying tumors, it is possible to use other radiation sources, for example, x-rays. Thereby search and development of x-ray activated photosensitizers is relevant at the moment. In this work a tungsten (W6I8) cluster complex was used as photo- and x-ray- sensitizer and its conjugate with DNA (W6I8DNA) as targeting molecules to eliminate Krebs-2 tumor cells and prevent tumor development in vivo.