Poster (download)
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Trifonova E.1, Zarubin A.2, Babovskaya A.3, Markov A.4, Stepanov V.5
1TNRMC RAS, Tomsk, Russia; SibMed, Tomsk, Russia, ekaterina.trifonova@medgenetics.ru
2TNRMC RAS, Tomsk, Russia, aleksei.zarubin@medgenetics.ru
3TNRMC RAS, Tomsk, Russia, anastasia.babovskaya@medgenetics.ru
4TNRMC RAS, Tomsk, Russia, anton.markov@medgenetics.ru
5TNRMC RAS, Tomsk, Russia, vadim.stepanov@medgenetics.ru
Preeclampsia is a complication of pregnancy characterized by new-onset hypertension and proteinuria of gestation, with serious consequences for mother and infant. Although a vast amount of research has been performed on the pathogenesis of preeclampsia, the underlying mechanisms of this multisystemic disease have remained to be fully elucidated. We identified the significant role of disturbance of intercellular interactions and regulation of proteins modification in placental tissue during the development of the PE. Among the genes involved in these key pathways, 9 hub genes and 3 master regulators were identified from the co-expression and upstream analysis networks. The present study may provide a basis for exploring potential novel genes and pathways as therapeutic targets for preeclampsia.