Daria Skuratovskaia1, Alexandra Komar2, Maria Vulf3, Egor Shunkin4, Larisa Litvinova5, Elena Kirienkova6
1Immanuel Kant Baltic Federal University, Dariask@list.ru
2Immanuel Kant Baltic Federal University, alexandkomar@gmail.com
3Immanuel Kant Baltic Federal University, mary-jean@yandex.ru
4Immanuel Kant Baltic Federal University, egor.shunkin@gmail.com
5Immanuel Kant Baltic Federal University, larisalitvinova@yandex.ru
6Immanuel Kant Baltic Federal University, elenamed@list.ru
According to the world community, metabolic complications are associated with inflammation in obesity. The cytokines of the interleukins (IL) – 6 family consist of IL-6, IL-11, IL-27 and have similar, but individual effects, such as the regulation of liver damage, the balance between regulatory and effector T cells and metabolic regulation. The anti-inflammatory and regenerative activities of IL-6 are usually mediated by the classical signaling regimen, while the pro-inflammatory responses in many pathological conditions include trans-signaling. The aim of the study was to assess the role of the cytokines of the IL-6 family: IL-6, sIL-6Ra, gp130 / sIL-6Rb, IL-11 in the regulation of carbohydrate (glucose level) and lipid (cholesterol (Hol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TR)) exchanges in serum / plasma in patients with metabolic syndrome (MetS). This fact may indicate the protective role of sIL-6Ra trans-signaling and protective role of IL-6 signal inhibition due to high levels of sgp130 / sIL-6Rb in relation to metabolic disorders in obesity patients.