Alexander V. Volchek1, Yulia S. Timofeeva2, Yanina M. Evseeva3, Dmitriy V. Morozov4, Igor O. Marinkin5, Svetlana V. Aidagulova6
1Novosibirsk State Medical University, alexander@volcheck.ru
2Novosibirsk State Medical University, dr.yustimofeeva@gmail.com
3Novosibirsk State Medical University, janinaevseeva@yahoo.com
4City Clinical Hospital в„–1, mdvil07@mail.ru
5Novosibirsk State Medical University, rectorngmu@yandex.ru
6Novosibirsk State Medical University, s.aydagulova@gmail.com
Cancer treatment shifts from mono-targeted to combination therapy, considering the tumor microenvironment with heparan sulfates, including Syndecan-1 (SDC1). The aim of this work was to study correlation between core-protein SDC1 and estrogen receptors expression in surgical material of 15 women aged 53,0В В±В 10,9 years with endometrioid ovarian cancer (EOC) using immunohistochemistry and automatic image analysis. The staining intensity of SDC1 in tumor tissue was 1304,23В В±В 65,85 units, the staining intensity of the estrogen receptors as 1137,88В В±В 135,40 units. The significant inverse correlation (RВ =В -В 0,512, p = 0,003) between SDC1 and estrogen receptors expression levels were obtained. Most likely, this deals with progressive character of EOC.