International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

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Cognitive Science and Genomics symposium

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Cognitive Science and Genomics symposiumDelta- and gamma-activity of resting state EEG as one of markers of risk of depressive disorders in migrants of subpolar and polar regions of Siberia

Delta- and gamma-activity of resting state EEG as one of markers of risk of depressive disorders in migrants of subpolar and polar regions of Siberia

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Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/489.pdf”]
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Natalya Milakhina1, Sergey Tamozhnikov2, Ekaterina Proshina3, Alexandra Karpova4, Alexander Savostyanov5, Elena Afanaseva6
1Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia, tashamilka@mail.ru
2State Scientific-Research Institute of Physiology & Basic Medicine, s.tam@physiol.ru
3State Scientific-Research Institute of Physiology & Basic Medicine, Novosibirsk, Russia, proshinaea@physiol.ru
4North-Eastern Federal University, Yakutsk, Russia, karpova74@list.ru
5Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia, a-sav@mail.ru
6North-Eastern Federal University, Yakutsk, Russia, eb.afanaseva@mail.ru

It is well known, the conditional rest state activates the functional rest network, including the brain default system (DMN) and the central executive network (CEN). At this stage of research, it can be assumed that both the process of adaptation to the polar climate and new social conditions, and the gradual reduction of the risk of depression among migrants, are due to functional changes within these two brain systems, as well as their functional relationships among themselves. Hypothetically, the increased activity of CEN is associated with a higher level of stress associated with moving to new living conditions

Cognitive Science and Genomics symposiumELECTROENCEPHALOGRAPHIC CORRELATES OF AN INSIGHT

ELECTROENCEPHALOGRAPHIC CORRELATES OF AN INSIGHT

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/495.pdf”]
Gennady Knyazev1, Andrey Bocharov2, Alexander Savostyanov3
1Institute of Physiology & Basic Medicine, knyazev@physiol.ru
2Institute of Physiology & Basic Medicine; Novosibirsk National Research State University, bocharov@physiol.ru
3Institute of Physiology & Basic Medicine; Novosibirsk National Research State University, a-sav@mail.ru

Insight is a quick, sudden penetration of the solution into the essence of the problem, which may be accompanied by a feeling of \”insight\”, or \” A-ha experience.\” The study of insights in the laboratory was fraught with significant difficulties and the results obtained were quite contradictory.In current study we aimed to identify the dynamics of brain activity in the period, preceding and accompanying the occurrence of insight using the distant association test (TOA) and EEG analysis at the level of sources of electrical activity. A comparison of the options for solving problems that were classified as “an insight” by subjects and those rated as “analytical” revealed a number of differences at behavioral and brain activity levels.Insight solutions were found averagely faster and were mostly more precise. Brain activity in solving problems in an analytical way did not significantly differ from brain activity while no solution was found, which allowed to suggest the presence of an analytical method in the latter case. The brain activity during problems solving using insights was significantly different from unsuccessful trails, and different from trails where an analytical strategy was used.The early stages of problem solution search showed the differences in the delta range in the cortical areas related to the default system and performance control networks. Brain activity, probably associated with the occurrence of an insight solution in the mind, was detected in beta and gamma ranges in the cortical areas of the left hemisphere, which were involved in semantic processes and emotional responses. All in all, the revealed effects showed distinct differences in the dynamics of brain activity with insight and analytical options for finding a solution and testified prospects of this research area. This work was supported by a grant from the Russian Foundation for Basic Research (RFFI) KOMFI No.18-00-00939 and No.18-00-00569.

Cognitive Science and Genomics symposiumDiabetes Type 2 as a Risk Factor of Neurodegeneration Development and Cognitive Impairment in db/db Mice

Diabetes Type 2 as a Risk Factor of Neurodegeneration Development and Cognitive Impairment in db/db Mice

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Poster (download)

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Tatyana A. Korolenko1, Nina I. Dubrovina2, Marina V. Ovsyukova3, Natalya P. Bgatova4, Chih-Li Lin5, Alexander B. Pupyshev6, Evgeniy L. Zavjalov7, Elena V. Anufrienko Scientific Research Institute8
1Scientific Research Institute of Physiology and Basic Medicine Novosibirsk, Russia, t.a.korolenko@physiol.ru
2Scientific Research Institute of Physiology and Basic Medicine Novosibirsk, Russia, dubrov@physiol.ru
3Scientific Research Institute of Physiology and Basic Medicine Novosibirsk, Russia, ovsyukovamv@physiol.ru
4Federal Research Center “ICG SB RAS”, Novosibirsk, Russia, n.bgatova@ngs.ru
5Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, dll@csmu.edu.tw
6Scientific Research Institute of Physiology and Basic Medicine Novosibirsk, Russia, apupyshev@physiol.ru
7Federal Research Center “ICG SB RAS”, Novosibirsk, Russia, zavjalov@bionet.nsc.ru
8Scientific Research Institute of Physiology and Basic Medicine Novosibirsk, Russia, anufrienko@ngs.ru

Diabetes T2 with insulin resistance is a serious disease all over the world with a tendency to steady increase the number of cases and a risk factor of neurodegenerative diseases development, among them firstly Alzheimer’s disease. The aim of this study was to investigate behavior and general characteristic of genetic model of diabetes T2 mice db/db, trying to reveal beginning of development early symptoms of neurodegeneration development and characteristic of symptoms of diabetes T2 during treatment by liraglutide or autophagy inducer trehalose. Mice age was 3 and 5 months. Db/db mice had an increase in body weight, which progressed with age, a decrease in brain mass. Blood glucose levels were increased in db/db mice. Treatment with trehalose or liraglutide reduces its level. Db/db mice were characterized by decrease of overall orientation-exploratory and locomotor activities, increase in anxiety in the open field test. Liraglutide treatment showed positive change in open field test in db/db mice. Passive avoidance test revealed significant decrease in motivation, locomotor and exploratory activity, decreased learning in db/db mice. Db/db mice of both ages were characterized by an increase in the relative number of PMN and monocytes and a decrease in the number of lymphocytes, indicating an inflammatory response. Treatment with trehalose or liraglutide restored these indicators. Thus, the identified behavioral changes in db/db mice reflected the development of neurodegeneration signs. Some positive effects of liraglutide on behavioral processes have been shown. Trehalose and liraglutide reduced blood glucose levels and the severity of the inflammatory response.