International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

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Systems Biology and Biomedicine symposium

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Systems Biology and Biomedicine symposiumSerum actin-binding proteins as markers of metastasis of larynx and laryngeal pharynx cancer

Serum actin-binding proteins as markers of metastasis of larynx and laryngeal pharynx cancer

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/151.pdf”]
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Kakurina G.V.1, Kolegova E.S2, Staheeva M.N.3, Cheremisina O.V.4, Kondakova I.V.5, Choynzonov E.L.6
1Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, kakurinagv@oncology.tomsk.ru
2Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, biochem@oncology.tomsk.ru
3Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, stakheyevam@oncology.tomsk.ru
4Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, onco@tnimc.ru
5Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, biochem@oncology.tomsk.ru
6Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, onco@tnimc.ru

To determine the markers of metastasis, it is important to study the molecular characteristics of tumor progression among patients with Squamous cell carcinoma of the larynx and larynxopharynx (L/L SCC). The aim of the study was to study the relationship between the level of actin binding proteins (ABS) (adenylyl cyclase-associated protein 1 (CAP1), cofilin 1, ezrin, fascin 1 and profilin 1) in the blood serum of patients with L/L SCC with the main clinical and morphological characteristics and to assess the possibility of their use as markers of metastasis. Several serum ABPs (CAP1, profilin1 and fascin 1) have been identified as potential markers of metastasis of L/L SCC. For the presented sample of patients a metastasis prognosis model was obtained. For further conclusions about the clinical value of the proposed metastasis markers, further studies with an expanding sample of patients are needed.

Systems Biology and Biomedicine symposiumLaser 3D-modeling in research of molecular features of skin lymphatic vessels in the patients with urticaria pigmentosa

Laser 3D-modeling in research of molecular features of skin lymphatic vessels in the patients with urticaria pigmentosa

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/149.pdf”]
Svetlana Viktorovna Michurina1, Svechnikova Natalia Nikolaevna2, Andrey Yurievich Letyagin3, Irina Yurievna Ishchenko4, Sergey Alekseevich Arkhipov5, Solovyova Anastasia Olegovna6, Konenkov Vladimir Iosifovich7
1Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, s.michurina@ngs.ru
2Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, n.svechnikova@ngs.ru
3Laboratory of pharmaceutical technologies SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, letyagin-andrey@yandex.ru
4Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, irenisch@mail.ru
5Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, arhipowsergei@yandex.ru
6Laboratory of pharmacological active compounds SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, solovevaao@gmail.com
7Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, vikonenkov@gmail.com

Congestion in the blood and lymphatic vessels is detected in the papillary and reticular layers in the skin dermis of patients with pigment urticarial. This promotes the development of microcirculatory disorders and the formation of perivascular infiltrates. LYVE-1 positive staining was detected not only in the endothelium of the lymphatic vessels (both in the skin papillary layer and in the deeper dermis layers), but also in the prickle cells of the stratum spinosum and (less pronounced) in the cells of the stratum basal in the epidermis. Our 3D modeling of the LYVE-1 marker expression in skin epidermis suggests that mainly the prickle cells of the epithelium stratum spinosum and to a lesser extent the cells of the epithelium basal layer in patients with cutaneous mastocytosis participate in the lymphatic transport of hyaluronan and the spaces between these cells can be considered as prelimfatiks of the skin epidermis.

Systems Biology and Biomedicine symposiumInfluence of the Factors of Maternal Milieu on Taste Preferences and Metabolic Parameters in Mouse Male and Female Offspring

Influence of the Factors of Maternal Milieu on Taste Preferences and Metabolic Parameters in Mouse Male and Female Offspring

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/140.pdf”]
Denisova Elena1, Makarova Elena2, Savinkova M3
1Laboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, RussiaLaboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, elena_nsib@list.ru
2Laboratory of Physiological Genetics Institute of Cytology and Genetics SB RAS Novosibirsk, Russia, enmakarova@gmail.com
3Department of Physiology Novosibirsk State University Novosibirsk, Russia, m.savinkova@g.nsu.ru

Ожидание в настоящее время является лидером среди неинфекционных заболеваний. Перегрузка калориями вызывает развитие ожирения. Было показано, что пренатальное и раннее постнатальное состояние влияет на восприимчивость к ожирению и может влиять на вкусовые предпочтения [1], однако механизмы, опосредующие материнское влияние на вкусовые предпочтения у потомства, неизвестны. Гормон лептина жировой ткани может быть одним из факторов, опосредующих материнское влияние на фенотип потомства. Было показано, что повышение уровня лепты в крови у беременных [2, 3] и программирование эффектов лептины могут быть различными у потомства разных полов.Неизвестно, связано ли это с положительным программным эффектом материнского лептина с предрасположенностью к его влиянию на вкусовые предпочтения. Эти исследования должны были повлиять на беременность, на мышечный метаболизм, частоту ожогов, вызванную диетой и вкусовыми предпочтениями у потомства разных полов.

Systems Biology and Biomedicine symposiumThe prevalence and the risk factors for low-energy fractures in women with type 2 diabetes

The prevalence and the risk factors for low-energy fractures in women with type 2 diabetes

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/122.pdf”]
Olga Fazullina1, Vadim Klimontov2
1RICEL – Branch of IC&G SB RAS, fazullina@ngs.ru
2RICEL – Branch of IC&G SB RAS, klimontov@mail.ru

Background and aim: The modeling of the risk of osteoporosis-related fractures in women with type 2 diabetes is important issue for medicine. The aim of our study was to determine the prevalence and the risk factors for low-energy fractures in postmenopausal women with type 2 diabetes.

Materials and Methods: The study included 236 postmenopausal women with type 2 diabetes, from 50 to 75 years of age. Bone mineral density (BMD), T-score and total body composition were determined by dual-energy X-ray absorptiometry.

Results: A reduced BMD was revealed in 150 women, including 45 individuals with osteoporosis and 105 subjects with osteopenia. A history of fractures occurred in 72 patients (30.5%). Low-energy fractures were observed in the groups of osteopenia (n=8) and osteoporosis (n=14). The most common localization of low-energy fractures was the radius (57.9% of all low-energy fractures), and proximal femur (36.8%). Women with low-energy fractures were older (p<0.001), had a lower body mass index (p<0.001), longer duration of insulin therapy and duration of postmenopause (p=0.01 and p<0.001 respectively). When analyzing the total body composition women with low-energy fractures had less total fat mass, abdominal and hip fat mass, and less lean mass (all p<0.001). In discriminant analysis, the duration of type 2 diabetes was the most reliable factor associated with low-energy fractures (model parameters: p=0.01; F=6.2; recognition accuracy 87%).

Conclusions: The age, duration of diabetes, postmenopause and insulin treatment, as well as body composition parameters (fat mass and lean mass), should be taken into consideration when modeling the risk of low-grade fractures in postmenopausal women with type 2 diabetes.

Systems Biology and Biomedicine symposiumBone remodeling in men with type 2 diabetes: is it just the same thing as in women?

Bone remodeling in men with type 2 diabetes: is it just the same thing as in women?

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/121.pdf”]
Olga Fazullina1, Vadim Klimontov2, Maksim Dashkin3
1RICEL – Branch of IC&G SB RAS, fazullina@ngs.ru
2RICEL – Branch of IC&G SB RAS, klimontov@mail.ru
3RICEL – Branch of IC&G SB RAS, mdashkin@invitro.ru

Background and aim: The mechanisms of reducing the bone mineral density (BMD) in men with type 2 diabetes are poorly understood. The aim of our study was to determine the relationships between the markers of bone remodeling and BMD in men with type 2 diabetes.

Materials and Methods: The study included 59 men with type 2 diabetes, from 50 to 75 years of age. BMD and T-score were determined by dual-energy X-ray absorptiometry. A serum levels of parathyroid hormone (PTH), free testosterone, osteocalcin, osteoprotegerin, sclerostin, and urinary excretion of C-terminal telopeptides of type I collagen (CTX-I) were determined by ELISA. Control group comprised of 21 healthy subjects with normal BMD, matched by sex and age.

Results: A reduced BMD was revealed in 29 patients, including 4 individuals with osteoporosis and 25 subjects with osteopenia. The levels of osteocalcin were decreased and the levels of osteoprotegerin and sclerostin were increased in observed diabetic subjects as compared to control (p=0.02, p<0.001 and p=0.02 respectively). The excretion of CTX-1 was reduced in patients with diabetes (p<0.001). There were no differences in PTH and free testosterone concentrations between control and diabetic subjects. In stepwise multivariate regression analysis, sclerostin was the most significant predictor for lumbar spine T-score (ОІ=0.496, R2=0.23, p=0.00007), the level of PTH influenced the femoral neck T-score (ОІ=-0.29, R2=0.26, p=0.005).

Conclusions: The obtained results suggest that the bone remodeling in men with type 2 diabetes is reduced due to the inhibition of osteoblastogenesis and decrease in the bone formation and resorption.

Systems Biology and Biomedicine symposiumThe effect of aluminum-silicon sorbent on the viability of lactobacilli at various pH indicators

The effect of aluminum-silicon sorbent on the viability of lactobacilli at various pH indicators

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/120.pdf”]
Tatiana V. Popova1, Irina S. Andreva2, Lubov N. Rachkovskay3, Anastasiya A. Kotlyarova4
1RICEL – Branch of IC&G SB RAS Novosibirsk, Russia, argentum.popova@mail.ru
2FBRI State Research Center of Virology and Biotechnology Vector of Rospotrebnadzor, Russia, andreeva@vector.nsc.ru
3RICEL – Branch of IC&G SB RAS Novosibirsk, Russia, noolit@niikel.ru
4RICEL – Branch of IC&G SB RAS Novosibirsk, Russia, kotlyarova@bionet.nsc.ru

This study was shown the dependence of the viability Lactobacillus cells bacteria on the interaction with the sorbent at different pH (7.0, 1.2, 8.0) of the medium. The study proved that the sorbent TAGA is an unfavorable factor for the microorganisms Lactobacillus acidophilus at pH 1.2