International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

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adolescents

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Genomics,  bioinformatics  and evolution symposiumGenetic aspects of internet-dependence in teenagers

Genetic aspects of internet-dependence in teenagers

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Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/56.pdf”]
Marina Smolnikova1, Sergey Tereshchenko2
1Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru
2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru

The rapid emergence and spread of Internet addiction in adolescent populations, combined with a rapid change in consumed content due to mobile access availability and the new access devices, are new challenges for classical psychology and fundamental medicine that require urgent solutions. The presence of the genetic component of Internet addiction was convincingly shown in different populations, but to date the specific genes involved in the mechanisms of such heritability have not been well identified. The aim of the study was to investigate the role of candidate neurotransmitters and to perform a population analysis of candidate genes polymorphisms for the Internet addiction formation. As a result of the analysis, 7 Internet-dependent adolescents and 39 adolescents with a tendency to Internet-dependent behavior were identified. The frequencies of genotype distribution in the population sampling of Caucasians (n = 302) В were obtained: * CC 59.6%, * CT 40.4%, * TT 0% (rs1800497 DRD2); * AA 23.8%, AG 52.4%, * GG 23.8% (rs4680 COMT); * CC 37.4%, * CG 46.0%, * GG 16.6% (rs2229910 NTRK3). The results will help to open new perspectives in assessing the fundamental neurobiological causes for the Internet addiction and the personalization of therapeutic approaches in Internet dependent adolescents.

Systems Biology and Biomedicine symposiumDysbiosis in the Gut Microbiota of Adolescents with Obesity

Dysbiosis in the Gut Microbiota of Adolescents with Obesity

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Novikova Evgenia Anatolyevna1, Bairova Tatyana Ananyevna2, Belkova Natalia Leonidovna3, Pogodina Anna Valeryevna4, Romanitsa Anastasia Igorevna5, Rychkova Lyubov Vladimirovna6
1Scientific РЎentre of Family Health and Human Reproduction Problems, europe411@mail.ru
2Scientific РЎentre of Family Health and Human Reproduction Problems, tbairova38@mail.ru
3Scientific РЎentre of Family Health and Human Reproduction Problems, nlbelkova@gmail.com
4Scientific РЎentre of Family Health and Human Reproduction Problems, pogodina_av@inbox.ru
5Scientific РЎentre of Family Health and Human Reproduction Problems, f1693@rambler.ru
6Scientific РЎentre of Family Health and Human Reproduction Problems, rychkova.nc@gmail.com

Gut microbiota plays a fundamental role in the pathogenesis of metabolic disorders including obesity. Gut microbial dysbiosis induces immune and metabolic disturbances. We wanted to find out a gut microbiota composition at adolescents with obesity and normal weight. The examined group included 40 adolescents. There were 18 obese adolescents with SDS BMI=2,77В±0,55 in the main group, and 22 adolescents with normal weight (SDS BMI=0,01В±0,50) in the control group. The metagenome sequencing of V3-V4 variable regions of 16S rDNA was done by Novogene Company (China).В  Data were analyzed using the StatSoft STATISTICA 10.0 software package. Statistical significance was accepted at the p<0.05 level. We did not find any variations between two groups in the main phylum Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and following genera Bacteroides, Alistipes, Subdoligranulum, Megasphaera, Blautia, Akkermansia, Odoribacter, Lactobacillus, Bifidobacterium. But for phylotypes Enterobacter and Anaerotruncus the differences in gut microbiota composition were found. The obese participants had a 2-fold decrease in Enterobacter (p=0.02), and an increase – in the Anaerotruncus phylotype (p=0.04). Summing up the results we might say that adolescents with obesity had decreased the number of the phylum Proteobacteria (the Enterobacter phylotype) and increased the level of the phylum Firmicutes (the Anaerotruncus phylotype).