International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

Tag

biomarker

3 RESULTS
Systems Biology and Biomedicine symposiumSemi-quantitative analysis of serum proteome in patients with bipolar disorder

Semi-quantitative analysis of serum proteome in patients with bipolar disorder

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Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/231.pdf”]
Seregin Alexander Alexandrovich1, Smirnova Lyudmila Pavlovna2, Simutkin German Gennadievich3
1Mental Health Research Institute Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, apocalips1991@mail.ru
2Mental Health Research Institute Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, lpsmirnova@yandex.ru
3Mental Health Research Institute Tomsk National Research Medical Center of the Russian Academy of Sciences Tomsk, Russia, ggsimutkin@gmail.com

The work analyzed the protein spectrum of blood serum of 45 with bipolar disorder. Protein recruitment in BD was mainly associated with the immune response, regulation of transport processes through the cell membrane and cellular communication, the development of neurons and oligodendrocytes, and cell growth. Cadherin-5 and vascular endothelial growth factor receptor 1 are a marker of endothelial dysfunction. The detection of these proteins suggests the presence of endothelial dysfunction in the pathogenesis of BD. The detection of myelin 1 transcription factor and the literature data on the effect of mutations in the MYT1L gene on the risk of major depressive disorder suggest the MYT1 protein as a potential BD biomarker. The results may help to discover new pathways associated BD.

Systems Biology and Biomedicine symposiumAmino acid and acylcarnitine levels relate with chronic schizophrenia

Amino acid and acylcarnitine levels relate with chronic schizophrenia

No Comment on Amino acid and acylcarnitine levels relate with chronic schizophrenia

Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/285.pdf”]
Irina Mednova1, Alexandr Chernonosov2, Marat Kasakin3, Elena Kornetova4, Arkadiy Semke5, Nikolay Bokhan6, Vladimir Koval7, Svetlana Ivanova8
1Mental Health Research Institute, TNRMC, Tomsk, Russia, irinka145@yandex.ru
2Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, alexander.chernonosov@niboch.nsc.ru
3Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, kassakinm@gmail.com
4Mental Health Research Institute, TNRMC, Tomsk, Russia, kornetova@sibmail.com
5Mental Health Research Institute, TNRMC, Tomsk, Russia, asemke@mail.ru
6Mental Health Research Institute, TNRMC, Tomsk, Russia, mental@tnimc.ru
7Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia, koval@niboch.nsc.ru
8Mental Health Research Institute, TNRMC, Tomsk, Russia, ivanovaniipz@gmail.com

Amino acids and acylcarnitines play important role as substrates and intermediate products in the most pathways related with schizophrenia. We found a significant decrease in the concentration of valine, aspartate, citrulline, glycine, arginine, glutamate and ornithine as well as C14, C14OH, C16OH, C16:1, C16:1OH, РЎ18, C18OH, C18:1, РЎ18:1OH, C18:2OH and C5:1 and increase C4DC in patients with schizophrenia in comparison to the controls.

Systems Biology and Biomedicine symposiumQuantitative differences in the proteomic composition of the blood serum of patients with simple and paranoid schizophrenia

Quantitative differences in the proteomic composition of the blood serum of patients with simple and paranoid schizophrenia

No Comment on Quantitative differences in the proteomic composition of the blood serum of patients with simple and paranoid schizophrenia

Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/363.pdf”]
Video (download)

Liudmila Snirnova1
1Mental Health Research Institute, Tomsk National Researc Medical Center of the Russian Academy of Sciences, lpsmirnova@yandex.ru

The work analyzed the protein spectrum of blood serum of simple and paranoid schizophrenia. A set of proteins in schizophrenia was mainly associated with responsible for protein synthesis and the processes of transduction and translation; immune response, oxidative stress and apotosis, cell compataminization and cell contacts. In the blood serum of patients in the general group of schizophrenia, a significant increase in the number of RIPK1, mGluR6 receptors was revealed in comparison with healthy people. In addition, the amount of mGluR6 was significantly higher in patients with a simple form of schizophrenia than in patients with a paranoid form (p = 0.021). A quantitative assessment of the specific minor proteins that we studied using labeled standard peptides showed an increase in their number depending on the severity of the disease (a simple form of schizophrenia, leading negative symptoms)