Chemotherapeutic agent cisplatin suppresses stabilin-1-mediated clearance of EGF by tumor-associated macrophage
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Irina Larionova1, Elena Kazakova2, Artyem Kiselev3, Marina Patysheva4, Julia Kzhyshkowska5
1National Research Tomsk State University, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, larionova0903irina@mail.ru
2National Research Tomsk State University Tomsk, Russia, kazakova.e.o@mail.ru
3Almazov National Medical Research Centre, Saint Petersburg, Russia, artem.kiselyov@gmail.com
4National Research Tomsk State University, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, starin5@ya.ru
5National Research Tomsk State University, Tomsk, Russia, German Red Cross Blood Service Baden-WГјrttemberg – Hessen, Mannheim, Germany, julia.kzhyshkowska@googlemail.com
In this study we have demonstrated the suppression of receptor-mediated clearance of tumor-supportive factors EGF by cisplatin in tumor-associated macrophages. These results may be useful for the determining of the mechanisms of the interaction of TAMs and chemotherapy and the mechanism of macrophage-mediated tumor chemoresistance.