Syndecan-1 expression in ovarian endometrioid cancer tissue has negative correlation with estrogen status
Alexander V. Volchek1, Yulia S. Timofeeva2, Yanina M. Evseeva3, Dmitriy V. Morozov4, Igor O. Marinkin5, Svetlana V. Aidagulova6
1Novosibirsk State Medical University, alexander@volcheck.ru
2Novosibirsk State Medical University, dr.yustimofeeva@gmail.com
3Novosibirsk State Medical University, janinaevseeva@yahoo.com
4City Clinical Hospital в„–1, mdvil07@mail.ru
5Novosibirsk State Medical University, rectorngmu@yandex.ru
6Novosibirsk State Medical University, s.aydagulova@gmail.com
Cancer treatment shifts from mono-targeted to combination therapy, considering the tumor microenvironment with heparan sulfates, including Syndecan-1 (SDC1). The aim of this work was to study correlation between core-protein SDC1 and estrogen receptors expression in surgical material of 15 women aged 53,0В В±В 10,9 years with endometrioid ovarian cancer (EOC) using immunohistochemistry and automatic image analysis. The staining intensity of SDC1 in tumor tissue was 1304,23В В±В 65,85 units, the staining intensity of the estrogen receptors as 1137,88В В±В 135,40 units. The significant inverse correlation (RВ =В -В 0,512, p = 0,003) between SDC1 and estrogen receptors expression levels were obtained. Most likely, this deals with progressive character of EOC.