functional activity

Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/12.pdf”]
Alexander Lykov¹, Lubov Rachkovskaya², Olga Poveshchenko³, Maria Surovtseva⁴, Irina Kim⁵, Edmund Rachkovsky⁶, Alena Philippova^7
1Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, aplykov2@mail.ru
²Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru
³Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, poveschenkoov@yandex.ru
⁴Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, mfelde@ngs.ru
⁵Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kii5@yandex.ru
⁶Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru
⁷Municipal autonomous educational institution Education center Gornostay, alena.philippova2003@yandex.ru

Fibroblasts and mesenchymal stem cells are involved in damaged skin repair. Functional activity of the fibroblasts mesenchymal stem cells depends from environment, including antimicrobial preparations. Silver salts are one of the antimicrobial substances. Lithium salts exhibit not only a stabilizing effect on human mental responses, but also antitumor and autophagic effects. The “Bodyguard” hygienic composition contains both silver and lithium. The aim of the study was to study the effect of bound silver and lithium ions in the \”Bodyguard\” composition and in salt of silver nitrate and lithium of citric acid on human dermal fibroblasts (DFs) and bone-marrow mesenchymal stem cells (MSCs) functions. It has been shown that DFs in the presence of \”Bodyguard\” reduces proliferative activity and significantly increases care in apoptosis. At the same time, silver and lithium ions alone or in combination do not affect proliferation, enhance migration and reduce DFs apoptosis. It has been shown that MSCs proliferation increased under “Bodyguard” condition. Whereas, silver ions and lithium ions not have any effect on proliferation of MSCs, but influenced on myeloperoxidase activity, nitric oxide production, migration, and apoptosis. The more pronounced negative action of the “Bodyguard” is most likely due not to silver and lithium ions, but to the very structure of the carrier to which these ions are immobilized.