International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

Tag

gene polymorphism

5 RESULTS
Genomics,  bioinformatics  and evolution symposiumGenetic aspects of internet-dependence in teenagers

Genetic aspects of internet-dependence in teenagers

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Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/56.pdf”]
Marina Smolnikova1, Sergey Tereshchenko2
1Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru
2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru

The rapid emergence and spread of Internet addiction in adolescent populations, combined with a rapid change in consumed content due to mobile access availability and the new access devices, are new challenges for classical psychology and fundamental medicine that require urgent solutions. The presence of the genetic component of Internet addiction was convincingly shown in different populations, but to date the specific genes involved in the mechanisms of such heritability have not been well identified. The aim of the study was to investigate the role of candidate neurotransmitters and to perform a population analysis of candidate genes polymorphisms for the Internet addiction formation. As a result of the analysis, 7 Internet-dependent adolescents and 39 adolescents with a tendency to Internet-dependent behavior were identified. The frequencies of genotype distribution in the population sampling of Caucasians (n = 302) В were obtained: * CC 59.6%, * CT 40.4%, * TT 0% (rs1800497 DRD2); * AA 23.8%, AG 52.4%, * GG 23.8% (rs4680 COMT); * CC 37.4%, * CG 46.0%, * GG 16.6% (rs2229910 NTRK3). The results will help to open new perspectives in assessing the fundamental neurobiological causes for the Internet addiction and the personalization of therapeutic approaches in Internet dependent adolescents.

Systems Biology and Biomedicine symposiumGene polymorphism IL13 in moderate-to-severe asthmatic Siberian children with different diseases control

Gene polymorphism IL13 in moderate-to-severe asthmatic Siberian children with different diseases control

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Marina Smolnikova1, Nina Gorbacheva2, Marina Malinchik3, Sergey Tereshchenko4
1Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru
2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, n-n-gorbacheva@yandex.ru
3Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, seapearl1995@gmail.com
4Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru

Multifunctional cytokines, such as IL-13, play an important role in asthma pathogenesis. Several single nucleotide polymorphisms of cytokines are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory, especially with respect to asthma severity in children. Child with moderate-to-severe asthma were divided to patients uncontrolled course of the disease (n = 107) and controlled course of the disease (n = 95). The frequency of the CT genotype IL13 (rs1800925) in patients with controlled moderate-to-severe asthma was significantly higher in comparison with control (46,2% / 36,6%, OR 1,51, p=0,03). Was obtained statistically significant differences in the frequency of the TT genotype between the population sample (6,7%) and the group with uncontrolled asthma (15,5%, OR 1,65, p=0,03). The results have contributed to the data on the role of polymorphisms of IL-13 into the development of asthma in children as exemplified by a European population of East Siberia, Russia.

Cognitive Science and Genomics symposiumРЎognitive functions and polymorphism of the BDNF gene in patients with schizophrenia and healthy individuals

РЎognitive functions and polymorphism of the BDNF gene in patients with schizophrenia and healthy individuals

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Poster (download)

[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/300.pdf”]
Anastasiia Boiko1, Ekaterina Mikhalitskaya2, Elena Kornetova3, Svetlana Ivanova4
1Mental Health Research Institute Tomsk NRMC, anastasya-iv@yandex.ru
2Mental Health Research Institute Tomsk NRMC, uzen63@mail.ru
3Mental Health Research Institute Tomsk NRMC, kornetova@sibmail.com
4Mental Health Research Institute Tomsk NRMC, ivanovaniipz@gmail.com

In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders and it is an important predictor of the unfavorable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) plays an important role in cell differentiation, survival, long-term potentiation, synaptic plasticity, learning and memory. The aim of the research is to study cognitive functions in patients with schizophrenia and healthy persons, and identify associations between cognitive function and polymorphism of BDNF gene. It was a complex clinical and biological examination of 550 patients with schizophrenia and 485 healthy persons. Significant differences in the distribution of genotypes of polymorphism rs6265 in patients with schizophrenia and healthy individuals were not found. Assessment of cognitive functions was carried out in 160 patients with schizophrenia and 106 healthy individuals using the BACS scale. The data obtained indicate that according to all BACS tests, the indicators of cognitive function in patients with schizophrenia are significantly worse than in healthy controls. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected by performing subtests of the BACS scale.

Cognitive Science and Genomics symposiumAssociations of polymorphic variants of the genes of neurotrophic factors BDNF, NGF, NRG1 with remission in patients with depressive disorders

Associations of polymorphic variants of the genes of neurotrophic factors BDNF, NGF, NRG1 with remission in patients with depressive disorders

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Natalia Vyalova1, German Simutkin2, Nikolay Bokhan3, Svetlana Ivanova4
1Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, Natarakitina@yandex.ru
2Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ggsimutkin@gmail.com
3Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, bna909@gmail.com
4Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ivanovaniipz@gmail.com

The investigation the relationship between BDNF, NGF and NRG1 genotypes with remission in patients with MDD was made in a group of 208 patients. The study showed that rs3924999 of the NRG1 gene was associated with clinical remission, rated on the HDRS-17 scale on day 28 of antidepressant therapy.

Systems Biology and Biomedicine symposiumGenetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents

Genetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents

No Comment on Genetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents

Marina Smolnikova1, Sergey Tereshchenko2
1Laboratory of cell-molecular physiology and pathology Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS Krasnoyarsk, Russia, smarinv@yandex.ru
2Clinical department somatic and mental health of children Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS Krasnoyarsk, Russia, legise@mail.ru

Abstract As the use of the Internet grows, the issue of the pathological and problematic Internet use (PIU) as well as online games has been relevant. Research related to a family history of temperament and mental disorders has rapidly been developing. Having the genetic component of developing Internet addiction was shown by twin studies using various populations, however, to date, the specific genes involved in the mechanisms of such heritability are not exactly identified. Materials: Genotyping of rs4680 COMT and rs1044396 CHRNA4 in 345 adolescents with different severity of internet addiction (tested with Chen Internet Addiction Scale) were analyzed. Results: The predominant allelic variant rs4680*G COMT in Khakass teenagers regardless of the severity of Internet addiction compared with Russian teenagers have been shown. It is important that some significant differences have also been observed between Russian PIU (45.5%) and Khakas PIU (63.8%) (OR 0.47, p = 0.024). We revealed that rs1044396 CC genotype prevalence progressively increase with IA severity: AIU group (n=179) – 19.0%, MIU group (n=82) – 32.9%, and PIU group (n=84) – 34.5%. The CC variant of rs1044396 CHRNA4 showed significantly higher anxiety scores as compared with carriers of T-allele. Our results correspond to similar results in the adult in another populations and are pilot in Russia; they are important for understanding the pathogenesis of IA at an early stage of addiction formation.