International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology”

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immunoglobulins

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Systems Biology and Biomedicine symposiumImmunoglobulins with proteolytic activity as a biomarker of impaired humoral immune system in schizophrenia

Immunoglobulins with proteolytic activity as a biomarker of impaired humoral immune system in schizophrenia

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[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/473.pdf”]
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Evgeny Ermakov1, Valentina Buneva2, Georgy Nevinsky3
1ICBFM SB RAS, Novosibirsk, Russia; NSU, Novosibirsk, Russia, evgeny_ermakov@mail.ru
2ICBFM SB RAS, Novosibirsk, Russia; NSU, Novosibirsk, Russia, buneva@niboch.nsc.ru
3ICBFM SB RAS, Novosibirsk, Russia; NSU, Novosibirsk, Russia, nevinsky@niboch.nsc.com

Schizophrenia is known to be associated not only with imbalance in the neurotransmitter systems but also with immune system dysregulation. In this work, we found that pure polyclonal IgG preparations of patients with schizophrenia possess histone hydrolyzing proteolytic activity. The presence of proteolytic activity of IgGs is evidence of impaired humoral immune system in schizophrenia, which can be used as a biomarker for immunophenotyping of patients.