Associations of polymorphic variants of the genes of neurotrophic factors BDNF, NGF, NRG1 with remission in patients with depressive disorders
Natalia Vyalova1, German Simutkin2, Nikolay Bokhan3, Svetlana Ivanova4
1Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, Natarakitina@yandex.ru
2Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ggsimutkin@gmail.com
3Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, bna909@gmail.com
4Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ivanovaniipz@gmail.com
The investigation the relationship between BDNF, NGF and NRG1 genotypes with remission in patients with MDD was made in a group of 208 patients. The study showed that rs3924999 of the NRG1 gene was associated with clinical remission, rated on the HDRS-17 scale on day 28 of antidepressant therapy.