Endoglycosidase expression in pubocervical fascia is up-regulated in menopause patients with severe pelvic organs prolapse
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Svetlana V. Aidagulova1, Fedor A. Rakitin2, Mikhail Yu. Soluyanov3, Vadim V. Nimaev4, Igor O. Marinkin5
1Novosibirsk State Medical University, s.aydagulova@gmail.com
2Research Institute of Clinical and Experimental Lymphology – Branch ICG SB RAS, rakitinfedorr@mail.ru
3Research Institute of Clinical and Experimental Lymphology – Branch ICG SB RAS, msoluyanov@mail.ru
4Research Institute of Clinical and Experimental Lymphology – Branch ICG SB RAS, nimaev@gmail.com
5Novosibirsk State Medical University, rectorngmu@yandex.ru
Pelvic organs prolapse in women is very inconvenient age-dependent pathology. One of the causes of pelvic organs prolapse is considered so called undifferentiated dysplasia of connective tissue being genetically determined change in the morphogenesis of connective tissue. The aim of this work was to study heparanase expression in pubocervical fascia of menopause women with pelvic organ prolapse. As shown heparanase protein content was significantly up-regulated in cellular compartment of pubocervical fascia in patients with pelvic organs prolapse and prominent undifferentiated dysplasia of connective tissue degrees.В