Mathematical modeling of robust pattern formation in the Drosophila eye disc
Svetlana Surkova1, Vitaly Gursky2, Konstantin Kozlov3, Sergey Nuzhdin4, Maria Samsonova5
1SPbPU, St. Petersburg, Russia, surkova_syu@spbstu.ru
2Ioffe Institute, St. Petersburg,Russia, gursky@math.ioffe.ru
3SPbPU, St. Petersburg, Russia, kozlov_kn@spbstu.ru
4USC, Los Angeles, USA, snuzhdin@usc.edu
5SPbPU, St. Petersburg, Russia, m.samsonova@spbstu.ru
We apply mathematical modeling approach to study mechanisms underlying the robust formation of periodic pattern during the Drosophila eye development. Model is fitted to the preliminary quantitative data – concentrations of the main regulators of R8 cell selection and specification. We analyze how biological noise propagates within the model to explain the molecular mechanisms responsible for noise buffering.