Cytokines of the IL-6 family in the modulation of carbohydrate and lipid metabolism in patients with metabolic syndrome
Daria Skuratovskaia1, Alexandra Komar2, Maria Vulf3, Egor Shunkin4, Larisa Litvinova5, Elena Kirienkova6
1Immanuel Kant Baltic Federal University, Dariask@list.ru
2Immanuel Kant Baltic Federal University, alexandkomar@gmail.com
3Immanuel Kant Baltic Federal University, mary-jean@yandex.ru
4Immanuel Kant Baltic Federal University, egor.shunkin@gmail.com
5Immanuel Kant Baltic Federal University, larisalitvinova@yandex.ru
6Immanuel Kant Baltic Federal University, elenamed@list.ru
According to the world community, metabolic complications are associated with inflammation in obesity. The cytokines of the interleukins (IL) – 6 family consist of IL-6, IL-11, IL-27 and have similar, but individual effects, such as the regulation of liver damage, the balance between regulatory and effector T cells and metabolic regulation. The anti-inflammatory and regenerative activities of IL-6 are usually mediated by the classical signaling regimen, while the pro-inflammatory responses in many pathological conditions include trans-signaling. The aim of the study was to assess the role of the cytokines of the IL-6 family: IL-6, sIL-6Ra, gp130 / sIL-6Rb, IL-11 in the regulation of carbohydrate (glucose level) and lipid (cholesterol (Hol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TR)) exchanges in serum / plasma in patients with metabolic syndrome (MetS). This fact may indicate the protective role of sIL-6Ra trans-signaling and protective role of IL-6 signal inhibition due to high levels of sgp130 / sIL-6Rb in relation to metabolic disorders in obesity patients.