Differentially methylation of ANKRD53 and GATA3 genes in human miscarriages with trisomy 16
Poster (download)
[pdf-embedder url=”https://bgrssb.icgbio.ru/wp-content/uploads/2020/07/209.pdf”]
E. N. Tolmacheva1, S.A.Vasilyev2, O.Yu. Vasilyeva3, T.V. Nikitina4, E.A.Sazhenova5, A.V.Markov6, E.S. Serdyukova7, D.I. Zhigalina8, I.N.Lebedev9
1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, katetolmacheva35@gmail.com
2Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, stas.vasilyev@gmail.com
3Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, vasilyeva.o.yu@gmail.com
4Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, t.nikitina@medgenetics.ru
5Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, elena.sazhenova@mail.ru
6Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, anton.markov@medgenetics.ru
7National Research Tomsk State University, Tomsk, katya.serdyukova.1997@mail.ru
8Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, dasha_150291@mail.ru
9Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, igor.lebedev@medgenetics.ru
An excess dosage of the genes at the whole chromosome can lead to a disturbance of the epigenetic background of the entire genome. We analyzed the DNA methylation of several genes that are important for normal embryogenesis in miscarriages with aneuploidy and normal karyotype.