Accepted_test

The tissue-specific outcomes of TAD boundary disruption in Unc5b-Slc29a3 locus
by Pavel Salnikov | Veniamin Fishman | Institute of Cytology and Genetics | Institute of Cytology and Genetics
Abstract ID: 249
Event: BGRS-abstracts
Sections: [Sym 1] Section “Fundamental and applied 3D genomics”

In this study, we examined genes with broad activity profiles that are separated into two distinct TADs by a robust insulatory boundary. Specifically, we explore the consequences of CTCF binding sites deletion at Slc29a3/Unc5b locus, which includes genes crucial for development and viability, organized into two separate TADs by a conserved insulatory boundary. We showed that disruptions at the TAD boundary could lead to misregulation of these genes, providing insight into how genome organization affects transcriptional activity across different tissues.