Accepted_test

Impact of post-transcriptional regulation of expression of the gene encoding GSK3 protein kinase in the control of tissue homeostasis and survival in Drosophila melanogaster

by Andreev Y. A. | Pasyukova E. G. | National Research Center “Kurchatov Institute”, Moscow, Russia | National Research Center “Kurchatov Institute”, Moscow, Russia

Abstract ID: 269

Event: BGRS-abstracts

Sections: Section “Genetics and systems biology of aging”

Exposure to harmful stimuli as well as aging can disrupt homeostasis, leading to changes in gene expression and subsequent intracellular regulation of biochemical processes. Controlled disruption of homeostasis could provide a more detailed understanding of the processes occurring during aging and the development of pathologies. Glycogen synthase kinase (GSK3) is a highly conserved enzyme that plays a key role in numerous metabolic pathways. GSK3 has been implicated in the development of various pathological conditions such as Alzheimer's disease, diabetes, inflammatory diseases, and certain types of cancer. The aim of this study was to assess the impact of overexpression of normal and altered forms of GSK3 on the survival of D. melanogaster and the maintenance of homeostasis in different tissues such as the fat body and salivary glands.