Accepted_test

Brain serotonin (5-HT) is a principal player in the mechanisms of brain and behavioral plasticity. This neurotransmitter plays an important role in the regulation of multiple physiological functions and types of behavior. Polyfunctionality of the brain 5-HT is due to a large variety of the receptors mediating 5-HT action on neurons. Currently, 14 different subtypes of 5-HT receptors are known in 5-HT receptor superfamily. The recent data indicate that all receptor types have multiple signaling cascades and some of the receptors could couple with more than one G-protein. Additionally, some of receptors could form hererodimers with other brain receptors and proteins that significantly affect central nervous system functioning. Growing body of evidence indicate that receptors heterodimerization is an additional factor in the regulation of the functional activity of the brain neurotransmitter and neurotrophic systems and, hence, behavior. The obtained data draw attention to receptor complexes as new targets for pharmacological correction of behavioral pathologies.