Accepted_test

Dietary Lecithin Effects on the Behavior, Brain Metabolism, Mitochondrial and Cellular Structure of the Neurons in Mice
by Lidiya Boldyreva | Elena Kiseleva | Maryana Morozova | Snezhanna Medvedeva | Ksenia Morozova | Elena Kozhevnikova | Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia | Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Acad-emy of Sciences, Novosibirsk, Russia | Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia | Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia | Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Acad-emy of Sciences, Novosibirsk, Russia | Institute of Molecular and Cellular biology of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Abstract ID: 461
Event: BGRS-abstracts
Sections: [Sym 10] Section “General problems in the study of cognitive processes; models of cognitive activity”

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Lecithin is widely used as a neuroprotective and hepatoprotective drug, a dietary supplement and is the often component of food production as an emulsifier. Previously, we have shown that animals given the phospholipid mixture with food have shown serious behavioral changes. Also, our data demonstrate impaired mitochondrial function in intestinal cells of such animals. Soy lecithin consists up to 70% of the phospholipids mixture: phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidic acid. Here we investigate the effects of lecithin administration on the behavioral patterns, brain cells and metabolism in laboratory mice. After long-term and short-term feeding of healthy C57BL/6 laboratory mice with lecithin, significant deviations in social behavioral patterns were revealed. These behavioral changes were accompanied by changes in a number of metabolites levels identified by LC-MS analysis in the brain. TEM analysis revealed substantially altered structure of mitochondria in hypothalamus and amygdala regions of brain in animals with long-termly administered soy lecithin. In addition, synaptic vesicles were found to be of irregular size and shape, and the synaptic cleft formed a wider than normal brush-like structure. In experimental animals, high rate of the apoptosis of neurons and glial cells, as well as cellular membranes degradation, was more often observed. Our results indicate a significant effect of lecithin supplementation on brain function, metabolism and cellular structure of neurons in laboratory mice.